Evidence map›Paper›PMID 33272950›Full record

ArticleAJNR. American journal of neuroradiology2021

Pilot Study of Hyperpolarized

A W Autry, I Park, C Kline, H-Y Chen, J W Gordon, S Raber, C Hoffman, Y Kim, K Okamoto, D B Vigneron and 5 more

Open access · bronzeAbstract readClinical Trial, Phase I
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Enhanced Glioblastoma Detection ThroughMagnetic resonance in medicine · 2026
    Article
  2. A Static Phantom for Harmonization of Hyperpolarized [1-Magnetic resonance in medicine · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Clinical Translation of HyperpolarizedAJNR. American journal of neuroradiology · 2025
    Review
  7. Review
  8. Quo Vadis HyperpolarizedZeitschrift fur medizinische Physik · 2025
    Review
  9. Current methods for hyperpolarized [1-Magnetic resonance in medicine · 2024
    Review
  10. Review
  11. Article
  12. Review
  13. Hyperpolarized [2-NeuroImage · 2023
    Article
  14. Review
  15. Review
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 6 countries.

A W AutryFrom the Departments of Radiology and Biomedical Imaging (A.W.A., H.-Y.C., J.W.G., Y.K., K.O., D.B.V., J.M.L., Y.L., D.X.).ORCID 0000-0002-7062-4965
I ParkDepartment of Radiology (I.P.), Chonnam National University College of Medicine and Hospital, Gwangju, Korea.ORCID 0000-0001-6022-8363
C KlineDivision of Hematology/Oncology (C.K., S.R., C.H., M.P., S.M.), Department of Pediatrics.ORCID 0000-0001-7765-7690
H-Y ChenFrom the Departments of Radiology and Biomedical Imaging (A.W.A., H.-Y.C., J.W.G., Y.K., K.O., D.B.V., J.M.L., Y.L., D.X.).ORCID 0000-0002-2765-1685
J W GordonFrom the Departments of Radiology and Biomedical Imaging (A.W.A., H.-Y.C., J.W.G., Y.K., K.O., D.B.V., J.M.L., Y.L., D.X.).ORCID 0000-0003-2760-4886
S RaberDivision of Hematology/Oncology (C.K., S.R., C.H., M.P., S.M.), Department of Pediatrics.ORCID 0000-0002-0297-0559
C HoffmanDivision of Hematology/Oncology (C.K., S.R., C.H., M.P., S.M.), Department of Pediatrics.ORCID 0000-0003-0831-4285
Y KimFrom the Departments of Radiology and Biomedical Imaging (A.W.A., H.-Y.C., J.W.G., Y.K., K.O., D.B.V., J.M.L., Y.L., D.X.).ORCID 0000-0003-1016-1572
K OkamotoFrom the Departments of Radiology and Biomedical Imaging (A.W.A., H.-Y.C., J.W.G., Y.K., K.O., D.B.V., J.M.L., Y.L., D.X.).ORCID 0000-0001-7966-8844
D B VigneronFrom the Departments of Radiology and Biomedical Imaging (A.W.A., H.-Y.C., J.W.G., Y.K., K.O., D.B.V., J.M.L., Y.L., D.X.).ORCID 0000-0001-5795-8699
J M LupoFrom the Departments of Radiology and Biomedical Imaging (A.W.A., H.-Y.C., J.W.G., Y.K., K.O., D.B.V., J.M.L., Y.L., D.X.).ORCID 0000-0002-0051-6387
M PradosDivision of Hematology/Oncology (C.K., S.R., C.H., M.P., S.M.), Department of Pediatrics.ORCID 0000-0002-9630-2075
Y LiFrom the Departments of Radiology and Biomedical Imaging (A.W.A., H.-Y.C., J.W.G., Y.K., K.O., D.B.V., J.M.L., Y.L., D.X.).ORCID 0000-0003-2145-2869
D XuFrom the Departments of Radiology and Biomedical Imaging (A.W.A., H.-Y.C., J.W.G., Y.K., K.O., D.B.V., J.M.L., Y.L., D.X.) Duan.Xu@ucsf.edu.ORCID 0000-0003-0550-4235
S MuellerDivision of Hematology/Oncology (C.K., S.R., C.H., M.P., S.M.), Department of Pediatrics.ORCID 0000-0002-3452-5150
Laboratoire d’Imagerie Biomédicale · FRI.R.C.C.S. Oasi Maria SS · ITUniversity of California, San Francisco · USChonnam National University Hospital · KR

Funding

Training Program in Translational Brain Tumor ResearchT32CA151022 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2010 to 2026
$6.6M
Research Training in Childhood CancerT32CA128583 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Eric Alejandro Sweet-Cordero · 2007 to 2026
$6.0M
NCI NIH HHS T32 CA128583NCI NIH HHS T32 CA151022
6 · The paper itself

Abstract

background and purposePediatric CNS tumors commonly present challenges for radiographic interpretation on conventional MR imaging. This study sought to investigate the safety and tolerability of hyperpolarized carbon-13 (HP- MATERIALS AND

methodsPediatric patients 3 to 18 years of age who were previously diagnosed with a brain tumor and could undergo MR imaging without sedation were eligible to enroll in this safety study of HP [1-

resultsBetween February 2017 and July 2019, ten participants (9 males; median age, 14 years; range, 10-17 years) were enrolled, of whom 6 completed injection of HP [1-

conclusionsDynamic HP-

Indexed as

Carbon IsotopesPyruvic AcidAdolescentBrain NeoplasmsChildDiffuse Intrinsic Pontine GliomaFemaleHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleNeuroimagingPilot ProjectsCarbon-13Carbon IsotopesPyruvic Acid

Identifiers

PMID33272950
PMCPMC7814790
OpenAlexW3106655399

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.