Evidence map›Paper›PMID 33272936›Full record

ArticleMolecular cancer research : MCR2021

Differential Effects of Clinically Relevant N- versus C-Terminal Truncating CDKN1A Mutations on Cisplatin Sensitivity in Bladder Cancer.

Rahmat K Sikder, Moataz Ellithi, Robert N Uzzo, David J Weader, Alexander L Metz, Ali Behbahani, Erica R McKenzie, Wafik S El-Deiry, Philip H Abbosh

Expression of concernOpen access · bronzeAbstract read
In one paragraph

Article in Molecular cancer research : MCR, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Revisiting the Function of p21International journal of molecular sciences · 2022
    Review
  6. Article
  7. CDKN1A/p21American journal of cancer research · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Rahmat K SikderMolecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
Moataz EllithiMolecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.ORCID 0000-0002-6261-4898
Robert N UzzoMolecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.ORCID 0000-0002-2440-6297
David J WeaderMolecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
Alexander L MetzMolecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
Ali BehbahaniCivil and Environmental Engineering, Temple University, Philadelphia, Pennsylvania.ORCID 0000-0003-2849-3030
Erica R McKenzieCivil and Environmental Engineering, Temple University, Philadelphia, Pennsylvania.ORCID 0000-0003-1982-2533
Wafik S El-DeiryMolecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
Philip H AbboshMolecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania. philip.abbosh@fccc.edu.
Fox Chase Cancer Center · USTemple University · US

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Dietmar J Kappes · 1985 to 2026
$138.8M
TIC10 anti-tumor effect through regulation of Foxo3a and TRAILR01CA173453 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI EL-DEIRY, WAFIK S. · 2013 to 2023
$4.3M
Targeting the oncogenic mutant p53 signaling in colorectal cancer therapyR01CA176289 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI EL-DEIRY, WAFIK S. · 2014 to 2018
$2.0M
Regulation of polymerase switching in translesion synthesisR01CA181178 · NCI · MAYO CLINIC ROCHESTER · PI MACHIDA, YUICHI · 2014 to 2018
$1.6M
Development of personalized surgical algorithms for muscle-invasive bladder cancer patientsR21CA218976 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI ABBOSH, PHILIP · 2017 to 2018
$438k
NCI NIH HHS P30 CA006927NCI NIH HHS R01 CA173453NCI NIH HHS R01 CA176289NCI NIH HHS R01 CA181178NCI NIH HHS R21 CA218976
6 · The paper itself

Abstract

Muscle-invasive bladder cancer (MIBC) frequently harbors mutations in the

Indexed as

CisplatinCyclin-Dependent Kinase Inhibitor p21HumansMutationUrinary Bladder NeoplasmsCDKN1A protein, humanCisplatinCyclin-Dependent Kinase Inhibitor p21

Identifiers

PMID33272936
PMCPMC7925368
OpenAlexW3109759561

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.