ArticleBrazilian journal of otorhinolaryngology
Impact of resection margin status and revision transoral laser microsurgery in early glottic cancer: analysis of organ preservation and local disease control on a cohort of 153 patients.
Article in Brazilian journal of otorhinolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 4 of them syntheses that pooled it.
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Who cites it
7 citing papers in PubMed, 4 syntheses or guidelines pooled it, 9 citations in OpenAlex.
- Prognostic significance of surgical margins in laryngeal cancer treated by transoral laser microsurgery: a systematic review and meta-analysis.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2025Pooled it
- Is COLasers in medical science · 2023Pooled it
- Thunderbeat®: a new step forward in transoral surgery-systematic review of literature and our experience.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023Pooled it
- Oncological Outcomes of Primary vs. Salvage OPHL Type II: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Papillomavirus Infection and Prevention: How Much Does the Sicilian Population Know? An Observational Study.International journal of environmental research and public health · 2022Observational
- Swallowing Outcomes in Open Partial Horizontal Laryngectomy Type I and Endoscopic Supraglottic Laryngectomy: A Comparative Study.International journal of environmental research and public health · 2022Article
- Quality of Life with Voice Prosthesis after Total Laryngectomy.Iranian journal of otorhinolaryngology · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
introductionTransoral laser microsurgery represents the treatment of choice for early glottic cancer. Its use and effectiveness are mainly related to laryngeal exposure and deep extension of tumor. Histopathologic assessment of surgical margin presents a main issue about transoral laser microsurgery and complete oncological excision.
objectiveThe aim was to analyze the impact of revision surgery on organ preservation and local disease control in patients with early glottic cancer treated by transoral laser microsurgery.
methodsWe carried out a retrospective study on a cohort of 153 patients with early glottic cancer (Tis, T1, T2) treated by transoral laser microsurgery. Resection margins were classified as follows: "free" if macroscopic margin-tumor distance was at least 2mm, as "close" if it was less than 2mm and "positive" if the margin was involved by carcinoma. Patients were divided into two groups: patients with free resection margins (Group A) and patients with positive, close or not-evaluable resection margins (Group B). Group A (36) underwent periodic followup. Group B (117) underwent a second look laser CO
resultsFive-year overall survival rate and 5-year disease-specific survival were 100% in both groups. The five-year laryngeal preservation rate was 100% in Group A and 95.2% in Group B. Five-year disease-free survival was 92.15% and 5-year ultimate local control with laser alone in 92.15% of patients.
conclusionThis study has demonstrated that revision Transoral Laser Microsurgery is able to confirm the oncological radicality in most cases, even in the case of positive, close or non-evaluable margins. Considering our results, according to our experience, the second look with CO
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