Evidence map›Paper›PMID 33272784›Full record

ReviewTrends in biochemical sciences2021

DEAH-Box RNA Helicases in Pre-mRNA Splicing.

Francesca De Bortoli, Sara Espinosa, Rui Zhao

Open access · greenAbstract readReview
In one paragraph

Review in Trends in biochemical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 82 citations in OpenAlex.

  1. Key Points to Consider When Studying RNA Remodeling by Proteins.Methods in molecular biology (Clifton, N.J.) · 2027
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  19. Unveiling the DHX15-G-patch interplay in retroviral RNA packaging.Proceedings of the National Academy of Sciences of the United States of America · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Francesca De BortoliDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Sara EspinosaDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Rui ZhaoDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Electronic address: rui.zhao@cuanschutz.edu.
University of Colorado Anschutz Medical Campus · US

Funding

Predoctoral Training Program in Molecular and Cellular Biology (Supplement: Mentoring in the Research Environment)T32GM136444 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI MICHAEL A MCMURRAY, Rytis Prekeris · 2020 to 2026
$3.7M
Understanding the structure and function of U1 snRNPR01GM126157 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI ZHAO, RUI · 2018 to 2021
$1.8M
Structure and function of spliceosomeR01GM130673 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI ZHAO, RUI · 2019 to 2021
$1.3M
NIGMS NIH HHS R01 GM126157NIGMS NIH HHS R01 GM130673NIGMS NIH HHS T32 GM136444
6 · The paper itself

Abstract

In eukaryotic cells, pre-mRNA splicing is catalyzed by the spliceosome, a highly dynamic molecular machinery that undergoes dramatic conformational and compositional rearrangements throughout the splicing cycle. These crucial rearrangements are largely driven by eight DExD/H-box RNA helicases. Interestingly, the four helicases participating in the late stages of splicing are all DEAH-box helicases that share structural similarities. This review aims to provide an overview of the structure and function of these DEAH-box helicases, including new information provided by recent cryo-electron microscopy structures of the spliceosomal complexes.

Indexed as

DEAD-box RNA HelicasesRNA PrecursorsCryoelectron MicroscopyRNA SplicingSpliceosomesDEAD-box RNA HelicasesRNA Precursorscryo-EMDEAH-box RNA helicasesspliceosome

Identifiers

PMID33272784
PMCPMC8112905
OpenAlexW3107814227

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.