Evidence map›Paper›PMID 33272604›Full record

ArticleThe Science of the total environment2021

Does solar ultraviolet radiation play a role in COVID-19 infection and deaths? An environmental ecological study in Italy.

Giancarlo Isaia, Henri Diémoz, Francesco Maluta, Ilias Fountoulakis, Daniela Ceccon, Alcide di Sarra, Stefania Facta, Francesca Fedele, Giuseppe Lorenzetto, Anna Maria Siani and 1 more

Abstract read
In one paragraph

Article in The Science of the total environment, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Systemic effects of sunlight: 10-year review of cardiovascular, infection and cancer outcomes.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Linkages between COVID-19, solar UV radiation, and the Montreal Protocol.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023
    Article
  9. Article
  10. Article
  11. Relationship between Vitamin D and Immunity in Older People with COVID-19.International journal of environmental research and public health · 2023
    Review
  12. Article
  13. Review
  14. Environment and COVID-19 incidence: A critical review.Journal of environmental sciences (China) · 2023
    Review
  15. Observational
  16. Air pollution and meteorological variables' effects on COVID-19 first and second waves in Spain.International journal of environmental science and technology : IJEST · 2023
    Article
  17. Article
  18. Review
  19. Review
  20. Ecological studies of COVID-19 and air pollution: How useful are they?Environmental epidemiology (Philadelphia, Pa.) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Giancarlo IsaiaDepartment of Medical Sciences, University of Turin, Italy; Academy of Medicine of Turin, Italy. Electronic address: giancarlo.isaia@unito.it.
Henri DiémozRegional Environmental Protection Agency (ARPA), Valle d'Aosta, Italy.
Francesco MalutaDepartment of Industrial Chemistry, University of Bologna, Italy.
Ilias FountoulakisRegional Environmental Protection Agency (ARPA), Valle d'Aosta, Italy.
Daniela CecconProvincial Environmental Protection Agency (APPA), Bolzano, Italy.
Alcide di SarraItalian Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), Italy.
Stefania FactaRegional Environmental Protection Agency (ARPA), Piemonte, Italy.
Francesca FedeleRegional Environmental Protection Agency (ARPA), Puglia, Italy.
Giuseppe LorenzettoRegional Environmental Protection Agency (ARPA), Veneto, Italy.
Anna Maria SianiSapienza University of Rome, Italy.
Gianluca IsaiaGeriatrics and Metabolic Bone Diseases, AOU Città della Salute e della Scienza of Turin, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A significantly stronger impact in mortality and morbidity by COVID-19 has been observed in the northern Italian regions compared to the southern ones. The reasons of this geographical pattern might involve several concurrent factors. The main objective of this work is to investigate whether any correlations exist between the spatial distribution of COVID-19 cases and deaths in the different Italian regions and the amount of solar ultraviolet (UV) radiation at the Earth's surface. To this purpose, in this environmental ecological study a mixed-effect exponential regression was built to explain the incidence of COVID-19 based on the environmental conditions, and demographic and pathophysiologic factors. Observations and estimates of the cumulative solar UV exposure have been included to quantify the amount of radiation available e.g., for pre-vitamin D3 synthesis or SARS-CoV-2 inactivation by sunlight. The analysis shows a significant correlation (p-value <5 × 10

Indexed as

COVID-19Ultraviolet RaysHumansItalyPandemicsSARS-CoV-2Clinical outcomes in ItalyCOVID-19Hypovitaminosis DTropospheric Emission Monitoring Internet Service (TEMIS)Ultraviolet radiation

Identifiers

PMID33272604
PMCPMC7678486

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.