Evidence map›Paper›PMID 33272206›Full record

ArticleThe journal of headache and pain2020

The role of deficient pain modulatory systems in the development of persistent post-traumatic headaches following mild traumatic brain injury: an exploratory longitudinal study.

Kelly M Naugle, Christopher Carey, Eric Evans, Jonathan Saxe, Ryan Overman, Fletcher A White

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of headache and pain, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

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  20. Models for Treating Post-traumatic Headache.Current pain and headache reports · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Kelly M NaugleDepartment of Kinesiology, School of Health and Human Sciences, Indiana University Purdue University Indianapolis (IUPUI), 901 West New York St., Indianapolis, IN, 46202, USA. kmnaugle@iupui.edu.ORCID http://orcid.org/0000-0001-5051-5625
Christopher CareyDepartment of Kinesiology, School of Health and Human Sciences, Indiana University Purdue University Indianapolis (IUPUI), 901 West New York St., Indianapolis, IN, 46202, USA.
Eric EvansDepartment of Health Sciences, School of Health and Human Sciences, IUPUI, 250 University Boulevard, Indianapolis, IN, 46202, USA.
Jonathan SaxeTrauma Department, Ascension St. Vincent Indianapolis Hospital, 2001 W 86th St, Indianapolis, IN, 46260, USA.
Ryan OvermanDepartment of Neurology, Indiana University School of Medicine, GH 4700 Neur, IN, 46202, Indianapolis, USA.
Fletcher A WhiteDepartment of Anesthesia, School of Medicine, Indiana University, 320 West 15th Street, Indianapolis, IN, 46202, USA.
Indiana University – Purdue University Indianapolis · USIndiana University School of MedicineSt Vincent Hospital · US

Funding

The role of cell-specific TLR-4 signaling in oxaliplatin-induced peripheral neuropathyR01NS102415 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI WHITE, FLETCHER A · 2018 to 2022
$2.2M
Indiana State Department of Health's Indiana Spinal Cord and Brain Injury Fund Research Grant Program N/ANINDS NIH HHS R01 NS102415St. Vincent's Foundation (AU) N/A
6 · The paper itself

Abstract

backgroundPost-traumatic headache (PTH) is one of the most common and long-lasting symptoms following mild traumatic brain injury (TBI). However, the pathological mechanisms underlying the development of persistent PTH remain poorly understood. The primary purpose of this prospective pilot study was to evaluate whether early pain modulatory profiles (sensitization and endogenous pain inhibitory capacity) and psychological factors after mild TBI predict the development of persistent PTH in mild TBI patients.

methodsAdult mild TBI patients recruited from Level I Emergency Department Trauma Centers completed study sessions at 1-2 weeks, 1-month, and 4-months post mild TBI. Participants completed the following outcome measures during each session: conditioned pain modulation to measure endogenous pain inhibitory capacity, temporal summation of pain and pressure pain thresholds of the head to measure sensitization of the head, Pain Catastrophizing Scale, Center for Epidemiological Studies - Depression Scale, and a standardized headache survey. Participants were classified into persistent PTH (PPTH) and no-PPTH groups based on the 4-month data.

resultsThe results revealed that mild TBI patients developing persistent PTH exhibited significantly diminished pain inhibitory capacity, and greater depression and pain catastrophizing following injury compared to those who do not develop persistent PTH. Furthermore, logistic regression indicated that headache pain intensity at 1-2 weeks and pain inhibitory capacity on the conditioned pain modulation test at 1-2 weeks predicted persistent PTH classification at 4 months post injury.

conclusionsOverall, the results suggested that persistent PTH is characterized by dysfunctional alterations in endogenous pain modulatory function and psychological processes in the early stages following mild TBI, which likely exacerbate risk for the maintenance of PTH.

Indexed as

Brain ConcussionPost-Traumatic HeadacheAdultHeadacheHumansLongitudinal StudiesPainPilot ProjectsProspective StudiesConditioned pain modulationMild traumatic brain injuryPain catastrophizingPain modulationPosttraumatic headache

Identifiers

PMID33272206
PMCPMC7712573
OpenAlexW3107266681

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.