Evidence map›Paper›PMID 33272199›Full record

ReviewBMC bioinformatics2020

Tissue-associated microbial detection in cancer using human sequencing data.

Rebecca M Rodriguez, Vedbar S Khadka, Mark Menor, Brenda Y Hernandez, Youping Deng

Open access · goldAbstract readReview
In one paragraph

Review in BMC bioinformatics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Microbiota in cancer: current understandings and future perspectives.Signal transduction and targeted therapy · 2026
    Review
  2. Review
  3. The cancer microbiome.Advances in clinical chemistry · 2025
    Review
  4. Article
  5. NAR cancer · 2022
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Rebecca M RodriguezBioinformatics Core, Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii, Mānoa, Honolulu, HI, USA.
Vedbar S KhadkaBioinformatics Core, Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii, Mānoa, Honolulu, HI, USA. vedbar@hawaii.edu.ORCID http://orcid.org/0000-0002-8652-2904
Mark MenorBioinformatics Core, Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii, Mānoa, Honolulu, HI, USA.
Brenda Y HernandezEpidemiology, University of Hawaii Cancer Center, University of Hawaii, Honolulu, HI, USA. brenda@cc.hawaii.edu.
Youping DengBioinformatics Core, Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii, Mānoa, Honolulu, HI, USA. dengy@hawaii.edu.
University of Hawaiʻi at Mānoa · US

Funding

UH Hilo COP A&RP20GM103466 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Peter R Hoffmann · 2012 to 2026
$60.3M
The Role of gp120 on Cardiovascular Disease in People Living with HIVU54MD007601 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI JoAnn Umilani Tsark · 2017 to 2026
$59.5M
University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Pallav Pokhrel · 1996 to 2026
$56.2M
RESEARCH DESIGN AND BIOSTATISTICS COREU54MD007584 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI HEDGES, JERRIS ROBERT, MOKUAU, NOREEN · 2012 to 2018
$21.1M
Small Grants ProgramP30GM114737 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI NERURKAR, VIVEK RAMCHANDRA · 2015 to 2022
$8.1M
Profiling genome-wide circulating ncRNAs for the early detection of lung cancerR01CA223490 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI DENG, YOUPING · 2018 to 2022
$3.1M
Circulating lipid and miRNA markers for early detection of breast cancer among women with abnormal mammogramsR01CA230514 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI DENG, YOUPING · 2019 to 2023
$2.8M
NCI NIH HHS P30 CA071789NCI NIH HHS R01 CA223490NCI NIH HHS R01 CA230514NIGMS NIH HHS P20 GM103466NIGMS NIH HHS P20GM103466NIGMS NIH HHS P30 GM114737NIH HHS 5P30GM114737NIH HHS 5R01CA230514NIMHD NIH HHS 2U54MD007601-32NIMHD NIH HHS U54 MD007584NIMHD NIH HHS U54MD007584NIMHD NIH HHS U54 MD007601
6 · The paper itself

Abstract

Cancer is one of the leading causes of morbidity and mortality in the globe. Microbiological infections account for up to 20% of the total global cancer burden. The human microbiota within each organ system is distinct, and their compositional variation and interactions with the human host have been known to attribute detrimental and beneficial effects on tumor progression. With the advent of next generation sequencing (NGS) technologies, data generated from NGS is being used for pathogen detection in cancer. Numerous bioinformatics computational frameworks have been developed to study viral information from host-sequencing data and can be adapted to bacterial studies. This review highlights existing popular computational frameworks that utilize NGS data as input to decipher microbial composition, which output can predict functional compositional differences with clinically relevant applicability in the development of treatment and prevention strategies.

Indexed as

High-Throughput Nucleotide SequencingComputational BiologyHumansMicrobiotaNeoplasmsOrgan SpecificityCancer microbiomeComputational frameworksNGS

Identifiers

PMID33272199
PMCPMC7713026
OpenAlexW3108020655

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.