Evidence map›Paper›PMID 33272128›Full record

ArticleStroke2021

Medications as Traumatic Reminders in Patients With Stroke/Transient Ischemic Attack-Induced Posttraumatic Stress Disorder.

Nadia Liyanage-Don, Jeffrey Birk, Talea Cornelius, Gabriel Sanchez, Nathalie Moise, Donald Edmondson, Ian Kronish

Open access · bronzeAbstract read
In one paragraph

Article in Stroke, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Cardiac event-induced PTSD symptoms and continuous heart rate in coronary artery disease patients.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Observational
  8. A Public Health Perspective of Post-Traumatic Stress Disorder.International journal of environmental research and public health · 2022
    Review
  9. Article
  10. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Nadia Liyanage-DonCenter for Behavioral Cardiovascular Health, Columbia University Medical Center, New York, NY.
Jeffrey BirkCenter for Behavioral Cardiovascular Health, Columbia University Medical Center, New York, NY.
Talea CorneliusCenter for Behavioral Cardiovascular Health, Columbia University Medical Center, New York, NY.
Gabriel SanchezCenter for Behavioral Cardiovascular Health, Columbia University Medical Center, New York, NY.
Nathalie MoiseCenter for Behavioral Cardiovascular Health, Columbia University Medical Center, New York, NY.
Donald EdmondsonCenter for Behavioral Cardiovascular Health, Columbia University Medical Center, New York, NY.
Ian KronishCenter for Behavioral Cardiovascular Health, Columbia University Medical Center, New York, NY.
Columbia University Irving Medical Center · US

Funding

Roybal Center for Fearless Behavior Change - renewal Behavioral Intervention Development (BID) CoreP30AG064198 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Nathalie Moise · 2019 to 2026
$7.4M
Impact of Social-Interpersonal Factors in the ER on PTSD/Cardiac OutcomesR01HL117832 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DAVIDSON, KARINA W., EDMONDSON, DONALD · 2013 to 2017
$3.1M
Test of a new theory to explain excess risk in cardiac PTSDR01HL128310 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI EDMONDSON, DONALD · 2015 to 2018
$2.6M
PTSD, Medication Adherence, and Prognosis after Acute Coronary SyndromesR01HL123368 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DAVIDSON, KARINA W., KRONISH, IAN MATTHEW · 2014 to 2017
$1.6M
Patient health information preference and statin therapyK23HL121144 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI YE, SIQIN · 2014 to 2018
$784k
NHLBI NIH HHS K23 HL121144NHLBI NIH HHS R01 HL117832NHLBI NIH HHS R01 HL123368NHLBI NIH HHS R01 HL128310NIA NIH HHS P30 AG064198
6 · The paper itself

Abstract

background and purposePosttraumatic stress disorder (PTSD) symptoms are common after stroke/transient ischemic attack (TIA) and have been associated with medication nonadherence, potentially because medications serve as traumatic reminders of the prior stroke/TIA. This study examined associations between stroke/TIA-induced PTSD and aversive cognitions toward preventive medications.

methodsWe enrolled a cohort of patients presenting to the emergency department with suspected stroke/TIA. One month posthospitalization, we assessed PTSD symptoms specific to the index stroke/TIA using the PTSD checklist specific and asked patients how often (1) did thinking about your stroke medication make you feel nervous or anxious?; (2) did thinking about your stroke medication make you think about your risk for future strokes?; and (3) did you skip or avoid taking your stroke medication so you would not have to think about your stroke? Logistic regression models tested the association between PTSD symptoms and each aversive cognition, adjusting for age, sex, ethnicity, and depression.

resultsAmong 408 included patients, 11.0% had elevated PTSD symptoms. These patients were more likely to report that thinking about their stroke medication made them feel nervous or anxious (37.8% versus 9.9%,

conclusionsMedications may serve as traumatic reminders after stroke/TIA-induced PTSD, potentially leading to medication nonadherence.

Indexed as

AgedAged, 80 and overAnxietyCohort StudiesDrug-Related Side Effects and Adverse ReactionsDrug TherapyFemaleHumansIschemic Attack, TransientMaleMedication AdherenceMiddle AgedStress Disorders, Post-TraumaticStrokeTreatment Outcomeanxietyassociationdepressionemergencieshospitalization

Identifiers

PMID33272128
PMCPMC7894604
OpenAlexW3108437313

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.