Evidence map›Paper›PMID 33272096›Full record

ArticleProgress in transplantation (Aliso Viejo, Calif.)2021

The Utility of a Pre-Transplant Psychosocial Evaluation in Predicting Post-Liver Transplant Outcomes.

Jacqueline H Becker, Eyal Shemesh, Akhil Shenoy, Ailie Posillico, Christopher S Knight, Se-Kang Kim, Sander S Florman, Thomas Schiano, Rachel A Annunziato

Open access · greenAbstract read
In one paragraph

Article in Progress in transplantation (Aliso Viejo, Calif.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Material economic hardships are associated with adverse 1-year outcomes after pediatric liver transplantation: Prospective cohort results from the multicenter SOCIAL-Tx Study.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2025
    Observational
  7. Article
  8. Review
  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Jacqueline H BeckerDepartment of Medicine, 5925Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-2708-6046
Eyal ShemeshDepartment of Pediatrics, 5925Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Akhil ShenoyCenter for Liver Disease and Transplantation, 21611Columbia University Medical Center, New York, NY, USA.ORCID 0000-0001-8639-2751
Ailie PosillicoDepartment of Psychology, 5923Fordham University, Bronx, NY, USA.
Christopher S KnightDepartment of Psychology, 5923Fordham University, Bronx, NY, USA.
Se-Kang KimDepartment of Psychology, 5923Fordham University, Bronx, NY, USA.
Sander S Florman52100Recanati/Miller Transplantation Institute/Division of Liver Disease, Mount Sinai Medical Center, New York, NY, USA.
Thomas Schiano52100Recanati/Miller Transplantation Institute/Division of Liver Disease, Mount Sinai Medical Center, New York, NY, USA.
Rachel A AnnunziatoDepartment of Pediatrics, 5925Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Fordham University · USMount Sinai Hospital · USIcahn School of Medicine at Mount Sinai · USColumbia University Irving Medical Center · US

Funding

Medication Adherence in Children Who Had a Liver Transplant (MALT)R01DK080740 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SHEMESH, EYAL · 2009 to 2014
$3.3M
Research Training for the Care of Vulnerable Older Adults with Alzheimer’s Disease and Related Dementias and Other Chronic ConditionsT32AG066598 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Alex D Federman · 2020 to 2026
$2.3M
NIA NIH HHS T32 AG066598NIDDK NIH HHS R01 DK080740
6 · The paper itself

Abstract

backgroundThere is insufficient evidence about the ability of pretransplant psychosocial evaluations to predict posttransplant outcomes. While standardized assessments were developed to increase predictive validity, it is unclear whether the risk scores they yield predict outcomes. We investigated if the Stanford Integrated Psychosocial Assessment for Transplantation (SIPAT), a scaling approach to those assessments, would have been a superior predictor than the standard psychosocial evaluation.

methodsIn this retrospective study, medical records of 182 adult liver transplant recipients who were at least 1 year posttransplant and prescribed tacrolimus for immunosuppression were analyzed. Regression analyses predicted outcomes of interest, including immunosuppressant nonadherence and biopsy-proven rejection, obtained 1-year posttransplant to time of data collection. Nonadherence was determined using the medication level variability index (MLVI).

resultsApproximately 49% of patients had MLVI > 2.5, suggestive of nonadherence, and 15% experienced rejection. SIPAT total score did not predict adherence either using the continuous (P = .70), or dichotimized score, above or below > 2.5 (P = .14), or rejection (P = 0.87). Using a SIPAT threshold (total score > 69) did not predict adherence (p = .16) nor was a superior predictor of the continuous adherence score (P = .45), MLVI > 2.5 (P = .42), or rejection (P = 0.49), than the standard evaluation.

conclusionOur findings suggest that the SIPAT is unable to predict 2 of the most important outcomes in this population, immunosuppressant adherence and rejection. Research efforts should attempt to evaluate the best manner to use psychosocial evaluations.

Indexed as

Liver TransplantationOrgan TransplantationAdultGraft RejectionHumansImmunosuppressive AgentsMedication AdherenceRetrospective StudiesTacrolimusImmunosuppressive AgentsTacrolimusliver transplantationnonadherencepsychosocial assessmentpsychosocial risktransplant evaluationtransplant outcomes

Identifiers

PMID33272096
PMCPMC7946723
OpenAlexW3108589181

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.