Evidence map›Paper›PMID 33271873›Full record

ArticleCells2020

Innovative Animal Model of DSS-Induced Ulcerative Colitis in Pseudo Germ-Free Mice.

Sona Gancarcikova, Stanislav Lauko, Gabriela Hrckova, Zuzana Andrejcakova, Vanda Hajduckova, Marian Madar, Livia Kolesar Fecskeova, Dagmar Mudronova, Kristina Mravcova, Gabriela Strkolcova and 5 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Sona GancarcikovaDepartment of Microbiology and Immunology, University of Veterinary Medicine and Pharmacy in Kosice, 041 81 Kosice, Slovakia.ORCID 0000-0003-3813-8657
Stanislav LaukoDepartment of Microbiology and Immunology, University of Veterinary Medicine and Pharmacy in Kosice, 041 81 Kosice, Slovakia.ORCID 0000-0002-8967-0822
Gabriela HrckovaInstitute of Parasitology, Slovak Academy of Sciences, 041 81 Kosice, Slovakia.
Zuzana AndrejcakovaDepartment of Biology and Physiology, University of Veterinary Medicine and Pharmacy in Kosice, 041 81 Kosice, Slovakia.ORCID 0000-0001-9929-0607
Vanda HajduckovaDepartment of Microbiology and Immunology, University of Veterinary Medicine and Pharmacy in Kosice, 041 81 Kosice, Slovakia.
Marian MadarDepartment of Microbiology and Immunology, University of Veterinary Medicine and Pharmacy in Kosice, 041 81 Kosice, Slovakia.ORCID 0000-0001-9347-2987
Livia Kolesar FecskeovaInstitute of Microbiology, Czech Academy of Sciences, Centre Algatech, 379 01 Trebon, Czech Republic.
Dagmar MudronovaDepartment of Microbiology and Immunology, University of Veterinary Medicine and Pharmacy in Kosice, 041 81 Kosice, Slovakia.ORCID 0000-0002-8007-6237
Kristina MravcovaDepartment of Epizootology, Parasitology and Protection of One Health, University of Veterinary Medicine and Pharmacy in Kosice, 041 81 Kosice, Slovakia.
Gabriela StrkolcovaDepartment of Epizootology, Parasitology and Protection of One Health, University of Veterinary Medicine and Pharmacy in Kosice, 041 81 Kosice, Slovakia.
Radomira NemcovaDepartment of Microbiology and Immunology, University of Veterinary Medicine and Pharmacy in Kosice, 041 81 Kosice, Slovakia.
Jana KacirovaDepartment of Microbiology and Immunology, University of Veterinary Medicine and Pharmacy in Kosice, 041 81 Kosice, Slovakia.
Andrea StaskovaDepartment of Stomatology and Maxilofacial Surgery, Pavol Jozef Safarik University in Kosice, 041 81 Kosice, Slovakia.
Stefan VilcekDepartment of Epizootology, Parasitology and Protection of One Health, University of Veterinary Medicine and Pharmacy in Kosice, 041 81 Kosice, Slovakia.ORCID 0000-0002-4658-561X
Alojz BombaInstitute of Experimental Medicine, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, 041 81 Kosice, Slovakia.
University of Veterinary Medicine in Košice · SKUniversity of Pavol Jozef Šafárik · SKCzech Academy of Sciences, Institute of Microbiology · CZSlovak Academy of Sciences · SK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to investigate the use of a standardized animal model subjected to antibiotic treatment, and the effects of this treatment on the course of dextran sodium sulphate (DSS)-induced colitis in mice. By decontamination with selective antibiotics and observation of pathogenesis of ulcerative colitis (UC) induced chemically by exposure of mice to various concentrations of DSS, we obtained an optimum animal PGF model of acute UC manifested by mucin depletion, epithelial degeneration and necrosis, leading to the disappearance of epithelial cells, infiltration of

Indexed as

AnimalsAnti-Bacterial AgentsApoptosisCell ProliferationColitis, UlcerativeDextran SulfateDisease Models, AnimalEpithelial CellsFemaleGastrointestinal MicrobiomeInflammationIntestinal MucosaMiceMice, Inbred BALB CAnti-Bacterial AgentsDextran SulfateantibioticsDSS-induced colitisgut microbiotahistopathologypseudo germ-free model

Identifiers

PMID33271873
PMCPMC7761014
OpenAlexW3109212742

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.