Evidence map›Paper›PMID 33271166›Full record

ArticleThe Journal of infection2021

A highly effective reverse-transcription loop-mediated isothermal amplification (RT-LAMP) assay for the rapid detection of SARS-CoV-2 infection.

Veronica L Fowler, Bryony Armson, Jose L Gonzales, Emma L Wise, Emma L A Howson, Zoe Vincent-Mistiaen, Sarah Fouch, Connor J Maltby, Seden Grippon, Simon Munro and 18 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of infection, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 3 pooled it
1.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 3 syntheses or guidelines pooled it, 100 citations in OpenAlex.

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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

28 authors at 7 institutions in 3 countries.

Veronica L FowlerHampshire Hospitals NHS Foundation Trust, Basingstoke & North Hampshire Hospital, Department of Microbiology, Basingstoke, UK; Eco Animal Health, The Grange, 100 The High Street, London, UK.
Bryony ArmsonHampshire Hospitals NHS Foundation Trust, Basingstoke & North Hampshire Hospital, Department of Microbiology, Basingstoke, UK; School of Veterinary Medicine, University of Surrey, Guildford, UK.
Jose L GonzalesWageningen Bioveterinary Research (WBVR), PO Box 65, 8200 AB Lelystad, the Netherlands.
Emma L WiseHampshire Hospitals NHS Foundation Trust, Basingstoke & North Hampshire Hospital, Department of Microbiology, Basingstoke, UK; School of Biosciences and Medicine, University of Surrey, Guildford, UK.
Emma L A HowsonGeneSys Biotech Limited, Camberley, Surrey, UK; The Pirbright Institute, Ash Road, Pirbright, Woking, UK.
Zoe Vincent-MistiaenHampshire Hospitals NHS Foundation Trust, Basingstoke & North Hampshire Hospital, Department of Microbiology, Basingstoke, UK; Gibraltar Health Authority, Gibraltar, UK.
Sarah FouchHampshire Hospitals NHS Foundation Trust, Basingstoke & North Hampshire Hospital, Department of Microbiology, Basingstoke, UK; School of Pharmacy and Biomedical Sciences, University of Portsmouth, UK.
Connor J MaltbyHampshire Hospitals NHS Foundation Trust, Basingstoke & North Hampshire Hospital, Department of Microbiology, Basingstoke, UK.
Seden GripponHampshire Hospitals NHS Foundation Trust, Basingstoke & North Hampshire Hospital, Department of Microbiology, Basingstoke, UK.
Simon MunroHampshire Hospitals NHS Foundation Trust, Basingstoke & North Hampshire Hospital, Department of Microbiology, Basingstoke, UK.
Lisa JonesHampshire Hospitals NHS Foundation Trust, Basingstoke & North Hampshire Hospital, Department of Microbiology, Basingstoke, UK.
Tom HolmesHampshire Hospitals NHS Foundation Trust, Basingstoke & North Hampshire Hospital, Department of Microbiology, Basingstoke, UK.
Claire TillyerHampshire Hospitals NHS Foundation Trust, Basingstoke & North Hampshire Hospital, Department of Microbiology, Basingstoke, UK.
Joanne ElwellHampshire Hospitals NHS Foundation Trust, Basingstoke & North Hampshire Hospital, Department of Microbiology, Basingstoke, UK.
Amy SowoodHampshire Hospitals NHS Foundation Trust, Basingstoke & North Hampshire Hospital, Department of Microbiology, Basingstoke, UK.
Oliver de PeyerHampshire Hospitals NHS Foundation Trust, Basingstoke & North Hampshire Hospital, Department of Microbiology, Basingstoke, UK.
Sophie DixonHampshire Hospitals NHS Foundation Trust, Basingstoke & North Hampshire Hospital, Department of Microbiology, Basingstoke, UK.
Thomas HatcherHampshire Hospitals NHS Foundation Trust, Basingstoke & North Hampshire Hospital, Department of Microbiology, Basingstoke, UK.
Helen PatrickHampshire Hospitals NHS Foundation Trust, Basingstoke & North Hampshire Hospital, Department of Microbiology, Basingstoke, UK.
Shailen LaxmanOptiSense Limited, Horsham, West Sussex, UK.
Charlotte WalshGeneSys Biotech Limited, Camberley, Surrey, UK.
Michael AndreouOptiSense Limited, Horsham, West Sussex, UK.
Nick MorantGeneSys Biotech Limited, Camberley, Surrey, UK.
Duncan ClarkGeneSys Biotech Limited, Camberley, Surrey, UK.
Nathan MooreHampshire Hospitals NHS Foundation Trust, Basingstoke & North Hampshire Hospital, Department of Microbiology, Basingstoke, UK.
Rebecca HoughtonHampshire Hospitals NHS Foundation Trust, Basingstoke & North Hampshire Hospital, Department of Microbiology, Basingstoke, UK.
Nicholas J CortesHampshire Hospitals NHS Foundation Trust, Basingstoke & North Hampshire Hospital, Department of Microbiology, Basingstoke, UK; Gibraltar Health Authority, Gibraltar, UK.
Stephen P KiddHampshire Hospitals NHS Foundation Trust, Basingstoke & North Hampshire Hospital, Department of Microbiology, Basingstoke, UK. Electronic address: stephen.kidd@hhft.nhs.uk.
Hampshire Hospitals NHS Foundation Trust · GBBasingstoke and North Hampshire Hospital · GBEast Sussex County Council · GBUniversity of Surrey · GBGibraltar Health Authority · GIThe Pirbright Institute · GBWageningen University & Research · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 pandemic has illustrated the importance of simple, rapid and accurate diagnostic testing. This study describes the validation of a new rapid SARS-CoV-2 RT-LAMP assay for use on extracted RNA or directly from swab offering an alternative diagnostic pathway that does not rely on traditional reagents that are often in short supply during a pandemic. Analytical specificity (ASp) of this new RT-LAMP assay was 100% and analytical sensitivity (ASe) was between 1 × 10

Indexed as

Clinical Laboratory TechniquesCOVID-19COVID-19 TestingHumansMass ScreeningMolecular Diagnostic TechniquesNucleic Acid Amplification TechniquesReal-Time Polymerase Chain ReactionRNA, ViralSalivaSARS-CoV-2Sensitivity and SpecificityRNA, ViralCOVID-19Direct RNA detectionNear patient testingRapid diagnosticsRT-LAMPSARS-CoV-2

Identifiers

PMID33271166
PMCPMC7703389
OpenAlexW3108001574

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.