Evidence map›Paper›PMID 33271065›Full record

ArticleThe Lancet. Infectious diseases2021

Ending deaths from HIV-related cryptococcal meningitis by 2030.

Amir Shroufi, Tom Chiller, Alex Jordan, David W Denning, Thomas S Harrison, Nelesh P Govender, Angela Loyse, Solange Baptiste, Radha Rajasingham, David R Boulware and 3 more

Abstract read
In one paragraph

Article in The Lancet. Infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Transcription Factors Fzc9 and Pdr802 Regulate ATP Levels and Metabolism inInternational journal of molecular sciences · 2025
    Article
  7. Evidence for the role of Irk2 and Irk5 in ATP and metabolism regulation inFrontiers in cellular and infection microbiology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Connecting Cryptococcal Meningitis and Gut Microbiome.International journal of molecular sciences · 2023
    Review
  12. Metals and the cell surface of Cryptococcus neoformans.Current opinion in microbiology · 2023
    Review
  13. Heme sensing and trafficking in fungi.Fungal biology reviews · 2023
    Article
  14. Roadmap for Achieving Universal Antiretroviral Treatment.Annual review of pharmacology and toxicology · 2023
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Amir ShroufiCDC Foundation, Cape Town, South Africa. Electronic address: amir.shroufi@doctors.org.uk.
Tom ChillerMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Alex JordanMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA.
David W DenningManchester Fungal Infection Group, The University of Manchester, Manchester, UK; Global Action Fund for Fungal Infections, Geneva, Switzerland.
Thomas S HarrisonCentre for Global Health, Institute of Infection and Immunity, St George's University of London, London, UK; MRC Centre for Medical Mycology, University of Exeter, Exeter, UK; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Nelesh P GovenderNational Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Angela LoyseCentre for Global Health, Institute of Infection and Immunity, St George's University of London, London, UK.
Solange BaptisteInternational Treatment Preparedness Coalition, Johannesburg, South Africa.
Radha RajasinghamDivision of Infectious Diseases and International Medicine, University of Minnesota, Minneapolis, MN, USA.
David R BoulwareDivision of Infectious Diseases and International Medicine, University of Minnesota, Minneapolis, MN, USA.
Isabela RibeiroDrugs for Neglected Diseases Initiative, Geneva, Switzerland.
Joseph N JarvisBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana; London School of Hygiene & Tropical Medicine, London, UK.
Gilles Van CutsemCentre for Infectious Disease Epidemiology and Research, University of Cape Town, Cape Town, South Africa; Southern Africa Medical Unit, Doctors Without Borders Southern Africa, Cape Town, South Africa.

Funding

Evaluation of CRAG screening with enhanced antifungal therapy for asymptomatic CRAG-positive personsK23AI138851 · NIAID · UNIVERSITY OF MINNESOTA · PI RAJASINGHAM, RADHA · 2018 to 2022
$954k
Department of Health RP-2017-08-ST2-012Medical Research Council G1100814Medical Research Council MC_PC_MR/P006922/1Medical Research Council MR/N006364/2NIAID NIH HHS K23 AI138851
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAgedAged, 80 and overAIDS-Related Opportunistic InfectionsAmphotericin BAntifungal AgentsFemaleFlucytosineGlobal HealthHIV InfectionsHumansMaleMeningitis, CryptococcalMiddle AgedAmphotericin BAntifungal AgentsFlucytosine

Identifiers

PMID33271065
PMCPMC8611658

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.