Evidence map›Paper›PMID 33270988›Full record

ArticleJournal of applied clinical medical physics2020

Using flattening filter free beams in electronic tissue compensation whole breast irradiation with deep inspiration breath hold.

Sarah B Wisnoskie, Xiaoying Liang, Andrew O Wahl, Nathan R Bennion, Andrew D Granatowicz, Sumin Zhou, Dandan Zheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied clinical medical physics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sarah B WisnoskieDepartment of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, USA.
Xiaoying LiangDepartment of Radiation Oncology, University of Florida Proton Institute, Jacksonville, FL, USA.
Andrew O WahlDepartment of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, USA.
Nathan R BennionDepartment of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, USA.
Andrew D GranatowiczDepartment of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, USA.
Sumin ZhouDepartment of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, USA.
Dandan ZhengDepartment of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, USA.
University of Nebraska Medical Center · USUniversity of Florida Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIn order to reduce heart dose, DIBH has become a common practice in left-sided whole breast irradiation. This technique involves a significant strain on patients due to the breath-hold requirements. We hereby investigate the dosimetric and delivery feasibility of using flattening filter free (FFF) energies with electronic tissue compensation (ECOMP) planning technique to reduce the required breath-hold lengths and increase patient compatibility.

methodsFifteen left-sided, postlumpectomy patients previously receiving DIBH whole-breast radiotherapy (266cGy x 16fx) were retrospectively planned using ECOMP for both 6X and 6X-FFF. A dosimetric comparison was made between the two plans for each patient using various dosimetric constraints. Delivery feasibility was analyzed by recalculating the 6X ECOMP plan with 6X-FFF without replanning (6X-FFF QA) and delivering both plans for a one-to-one comparison using Gamma analysis. Beam-on times for the 6X and 6X-FFF plans were measured. For all tests, Wilcoxon signed-rank test was used with P < 0.05 as significant.

resultsNo statistical difference was observed between 6X and 6X-FFF plans for most dosimetric endpoints except contralateral breast D

conclusionECOMP planning with FFF was found feasible for left-sided breast patients with DIBH. Plan quality is comparable, if not better, than plans using flattened beams. FFF ECOMP could significantly reduce beam-on time and required breath-hold lengths thereby increasing patient compatibility for this treatment while offering satisfactory plan quality and delivery accuracy.

Indexed as

Breath HoldingRadiotherapy, Intensity-ModulatedElectronicsHumansRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRetrospective Studiesbreast cancerbreath holdDIBHECOMPexternal beamFFF

Identifiers

PMID33270988
PMCPMC7769397
OpenAlexW3110583529

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.