ArticleCerebral cortex (New York, N.Y. : 1991)2021
The Parahippocampal Cortex and its Functional Connection with the Hippocampus are Critical for Nonnavigational Spatial Memory in Macaques.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Topography of Regional Cerebral GABAThe European journal of neuroscience · 2026Article
- Problematic patterns of social media use increase with spontaneous cortical activity and transdiagnostic mental health symptoms in youth.Developmental cognitive neuroscience · 2026Article
- Learning brain dynamics across distinct scaling regimes reveals psychiatric signatures.Communications biology · 2026Article
- Epicranial electrical stimulation improves non-navigational spatial memory in macaque monkeys.Neuroimage. Reports · 2026Article
- Structural alterations as a predictor of depression - a 7-Tesla MRI-based multidimensional approach.Molecular psychiatry · 2025Article
- White matter dysfunction in Alzheimer's disease is associated with disease-related transcriptomic signatures.Communications biology · 2025Article
- Comprehensive characterization of the transcriptional landscape in Alzheimer's disease (AD) brains.Science advances · 2025Article
- Targeting papez circuit for cognitive dysfunction- insights into deep brain stimulation for Alzheimer's disease.Heliyon · 2024Review
- Hippocampal lesions impair non-navigational spatial memory in macaques.Hippocampus · 2024Article
- Automatic detection of mild cognitive impairment based on deep learning and radiomics of MR imaging.Frontiers in medicine · 2024Article
- Multi-omic atlas of the parahippocampal gyrus in Alzheimer's disease.Scientific data · 2023Article
- Quinpirole, but not muscimol, infused into the nucleus accumbens disrupts prepulse inhibition of the acoustic startle in rhesus macaques.Neuropharmacology · 2023Article
- Macaques fail to develop habit responses during extended training on a reinforcer devaluation task.Behavioral neuroscience · 2022Article
- Intrahippocampal blockade of nicotinic or muscarinic receptors fails to impair nonnavigational spatial memory in macaques.Behavioral neuroscience · 2021Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The Hamilton Search Task (HST) is a test of nonnavigational spatial memory that is dependent on the hippocampus. The parahippocampal cortex (PHC) is a major route for spatial information to reach the hippocampus, but the extent to which the PHC and hippocampus function independently of one another in the context of nonnavigational spatial memory is unclear. Here, we tested the hypotheses that (1) bilateral pharmacological inactivation of the PHC would impair HST performance, and (2) that functional disconnection of the PHC and hippocampus by contralateral (crossed) inactivation would likewise impair performance. Transient inactivation of the PHC impaired HST performance most robustly with 30 s intertrial delays, but not when color cues were introduced. Functional disconnection of the PHC and hippocampus, but not separate unilateral inactivation of either region, also selectively impaired long-term spatial memory. These findings indicate a critical role for the PHC and its interactions with the hippocampus in nonnavigational spatial memory.
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