ArticlePLoS pathogens2020
A vector whitefly endocytic receptor facilitates the entry of begomoviruses into its midgut cells via binding to virion capsid proteins.
Article in PLoS pathogens, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- A bacterial symbiont and a plant virus enhance insect fitness by inducing physical defenses against fungal parasites.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Defender or accomplice? Dual roles of plant vesicle trafficking in restricting and enabling geminiviral systemic infection.The New phytologist · 2026Article
- Pathogen promotes insect ovarian development by inducing a dual role of host ATPSyn-β.Communications biology · 2026Article
- Tetraspanin SfCD9 as a Key Membrane Binding Factor of SRBSDV P10 Facilitates Viral Entry Into Sogatella furcifera Midgut Epithelial Cells via Clathrin-Mediated Endocytosis.Molecular plant pathology · 2025Article
- Development of a rapid isothermal-based assay for detection of whitefly MEAM1 and MED biotypes using recombinase polymerase amplification.Physiology and molecular biology of plants : an international journal of functional plant biology · 2025Article
- Heat stress promotes the accumulation of tomato yellow leaf curl virus in its insect vector by activating heat shock factor.Crop health · 2024Article
- Article
- A plant virus differentially alters DNA methylation in two cryptic species of a hemipteran vector.Npj viruses · 2024Article
- Coat protein of a whitefly-vectored plant virus as a delivery system to target whitefly.Microbial biotechnology · 2024Article
- The essential role of clathrin-mediated endocytosis and early endosomes in the trafficking of begomoviruses through the primary salivary glands of their whitefly vectors.Journal of virology · 2023Article
- F-actin dynamics in midgut cells enables virus persistence in vector insects.Molecular plant pathology · 2022Article
- Article
- PEBP balances apoptosis and autophagy in whitefly upon arbovirus infection.Nature communications · 2022Article
- Cotton leaf curl Multan virus differentially regulates innate antiviral immunity of whitefly (Frontiers in plant science · 2022Article
- Review
- Article
- Gut-Expressed Vitellogenin Facilitates the Movement of a Plant Virus across the Midgut Wall in Its Insect Vector.mSystems · 2021Article
- Implication of the Whitefly Protein Vps Twenty Associated 1 (Vta1) in the Transmission of Cotton Leaf Curl Multan Virus.Microorganisms · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many circulative plant viruses transmitted by insect vectors are devastating to agriculture worldwide. The midgut wall of vector insects represents a major barrier and at the same time the key gate a circulative plant virus must cross for productive transmission. However, how these viruses enter insect midgut cells remains poorly understood. Here, we identified an endocytic receptor complex for begomoviruses in the midgut cells of their whitefly vector. Our results show that two whitefly proteins, BtCUBN and BtAMN, compose a receptor complex BtCubam, for which BtCUBN contributes a viral-binding region and BtAMN contributes to membrane anchorage. Begomoviruses appear to be internalized together with BtCubam via its interaction with the 12-19 CUB domains of BtCUBN via clathrin-dependent endocytosis. Functional analysis indicates that interruption of BtCUBN and BtAMN lead to reduction of virus acquisition and transmission by whitefly. In contrast, CUBN-begomovirus interaction was not observed in two non-competent whitefly-begomovirus combinations. These observations suggest a major role of the specific endocytic receptor in facilitating viral entry into vector midgut cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.