ArticlePLoS genetics2020
Gene regulatory effects of a large chromosomal inversion in highland maize.
Article in PLoS genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 73 citations in OpenAlex.
- The MexMAGIC population reveals the genetic architecture of traits exhibiting clinal variation in Mexican native maize.The New phytologist · 2026Article
- Pan-genome analysis reveals structural variation- associated expression and evolutionary diversity of theFrontiers in plant science · 2026Article
- Screening of Monokaryotic Strains ofJournal of fungi (Basel, Switzerland) · 2025Article
- Next-generation translational genomics for developing future crops.Functional & integrative genomics · 2025Review
- Pan-Plastome Analysis Reveals the Genetic Diversity and Genetic Divergence ofInternational journal of molecular sciences · 2025Article
- A Balanced Inversion Polymorphism Exhibits a Dominance Reversal at the Gene Expression Level that Depends on Developmental Context.Molecular biology and evolution · 2025Article
- Iterative SCRaMbLE for engineering synthetic genome modules and chromosomes.Nature communications · 2025Article
- Epigenetic state and gene expression remain stable after CRISPR/Cas-mediated chromosomal inversions.The New phytologist · 2025Article
- Impact of Z chromosome inversions on gene expression in testis and liver tissues in the zebra finch.Molecular ecology · 2024Article
- Inversions encounter relaxed genetic constraints and balance birth and death of TPS genes in Curcuma.Nature communications · 2024Article
- Plant pangenomes for crop improvement, biodiversity and evolution.Nature reviews. Genetics · 2024Review
- A catalogue of recombination coldspots in interspecific tomato hybrids.PLoS genetics · 2024Article
- Multiplexed CRISPR-Cas9 mutagenesis of riceScience advances · 2024Article
- Regulation of gene-edited plants in Europe: from the valley of tears into the shining sun?aBIOTECH · 2024Review
- Pan-genome inversion index reveals evolutionary insights into the subpopulation structure of Asian rice.Nature communications · 2023Article
- Time-ordering japonica/geng genomes analysis indicates the importance of large structural variants in rice breeding.Plant biotechnology journal · 2023Article
- Allele-specific Expression Reveals Multiple Paths to Highland Adaptation in Maize.Molecular biology and evolution · 2022Article
- Genome sequencing reveals evidence of adaptive variation in the genus Zea.Nature genetics · 2022Article
- The influence of genetic architecture on responses to selection under drought in rice.Evolutionary applications · 2022Article
- Genetic architecture of repeated phenotypic divergence in Littorina saxatilis ecotype evolution.Evolution; international journal of organic evolution · 2022Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromosomal inversions play an important role in local adaptation. Inversions can capture multiple locally adaptive functional variants in a linked block by repressing recombination. However, this recombination suppression makes it difficult to identify the genetic mechanisms underlying an inversion's role in adaptation. In this study, we used large-scale transcriptomic data to dissect the functional importance of a 13 Mb inversion locus (Inv4m) found almost exclusively in highland populations of maize (Zea mays ssp. mays). Inv4m was introgressed into highland maize from the wild relative Zea mays ssp. mexicana, also present in the highlands of Mexico, and is thought to be important for the adaptation of these populations to cultivation in highland environments. However, the specific genetic variants and traits that underlie this adaptation are not known. We created two families segregating for the standard and inverted haplotypes of Inv4m in a common genetic background and measured gene expression effects associated with the inversion across 9 tissues in two experimental conditions. With these data, we quantified both the global transcriptomic effects of the highland Inv4m haplotype, and the local cis-regulatory variation present within the locus. We found diverse physiological effects of Inv4m across the 9 tissues, including a strong effect on the expression of genes involved in photosynthesis and chloroplast physiology. Although we could not confidently identify the causal alleles within Inv4m, this research accelerates progress towards understanding this inversion and will guide future research on these important genomic features.
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