Evidence map›Paper›PMID 33270480›Full record

ArticleHuman vaccines & immunotherapeutics2021

Need to take special care of non-responders to hepatitis B vaccination among health-care workers, students and chronic patients.

Angela Bechini, Paolo Bonanni, Maddalena Grazzini, Diana Paolini, Giulio Arcangeli, Nicola Mucci, Costanza Bini, Emilia Tiscione, Beatrice Zanella, Sara Boccalini

Open access · bronzeAbstract read
In one paragraph

Article in Human vaccines & immunotherapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Angela BechiniDepartment of Health Sciences, University of Florence , Florence, Italy.ORCID 0000-0002-6013-8779
Paolo BonanniDepartment of Health Sciences, University of Florence , Florence, Italy.ORCID 0000-0003-2875-3744
Maddalena GrazziniDepartment of Health Sciences, University of Florence , Florence, Italy.ORCID 0000-0003-4094-4551
Diana PaoliniDepartment of Health Sciences, University of Florence , Florence, Italy.ORCID 0000-0001-8062-5710
Giulio ArcangeliDepartment of Experimental and Clinical Medicine, University of Florence , Florence, Italy.
Nicola MucciDepartment of Experimental and Clinical Medicine, University of Florence , Florence, Italy.ORCID 0000-0003-0579-1035
Costanza BiniDepartment of Experimental and Clinical Medicine, University of Florence , Florence, Italy.
Emilia TiscioneDepartment of Health Sciences, University of Florence , Florence, Italy.ORCID 0000-0002-9279-5431
Beatrice ZanellaDepartment of Health Sciences, University of Florence , Florence, Italy.ORCID 0000-0001-6718-1932
Sara BoccaliniDepartment of Health Sciences, University of Florence , Florence, Italy.ORCID 0000-0002-9695-7549
University of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Both our research and that published by Sticchi et al. on immunological memory against hepatitis B virus (HBV) in health-care workers (HCWs) vaccinated as infants or adolescents confirm that in those testing negative after the primary course, one additional (fourth) booster dose is able to elicit an anti-HBs response in >85% subjects. The fifth and the sixth doses further contribute substantially to a high overall response rate. The rate of subjects showing an anamnestic response after the booster dose was almost six-fold higher in HCWs compared to chronic patients. Since universal vaccination in Italy resulted in a significant decrease in HBV infections, special attention and testing should be addressed to those affected by chronic diseases.

Indexed as

Hepatitis BHepatitis B AntibodiesAdolescentHepatitis B Surface AntigensHepatitis B VaccinesHumansImmunization, SecondaryImmunologic MemoryInfantItalyStudentsVaccinationHepatitis B AntibodiesHepatitis B Surface AntigensHepatitis B Vaccinesadditional dosesanti-HBs testingchronic patientshealthcare workersHepatitis Bnon-respondersvaccination

Identifiers

PMID33270480
PMCPMC7899626
OpenAlexW3110425060

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.