Evidence map›Paper›PMID 33270461›Full record

ArticleThe journal of physical chemistry. B2020

Site of Azido Substitution in the Sugar Moiety of Azidopyrimidine Nucleosides Influences the Reactivity of Aminyl Radicals Formed by Dissociative Electron Attachment.

Mukesh Mudgal, Thao P Dang, Adam J Sobczak, Daniel A Lumpuy, Priya Dutta, Samuel Ward, Katherine Ward, Moaadh Alahmadi, Anil Kumar, Michael D Sevilla and 2 more

Open access · greenAbstract read
In one paragraph

Article in The journal of physical chemistry. B, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Nitrogen-Centered Radicals Derived from Azidonucleosides.Molecules (Basel, Switzerland) · 2024
    Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Mukesh MudgalDepartment of Chemistry and Biochemistry, Florida International University, Miami, Florida 33199, United States.
Thao P DangDepartment of Chemistry and Biochemistry, Florida International University, Miami, Florida 33199, United States.
Adam J SobczakDepartment of Chemistry and Biochemistry, Florida International University, Miami, Florida 33199, United States.
Daniel A LumpuyDepartment of Chemistry and Biochemistry, Florida International University, Miami, Florida 33199, United States.
Priya DuttaDepartment of Chemistry, Oakland University, 146 Library Drive, Rochester, Michigan 48309, United States.
Samuel WardDepartment of Chemistry, Oakland University, 146 Library Drive, Rochester, Michigan 48309, United States.
Katherine WardDepartment of Chemistry, Oakland University, 146 Library Drive, Rochester, Michigan 48309, United States.
Moaadh AlahmadiDepartment of Chemistry, Oakland University, 146 Library Drive, Rochester, Michigan 48309, United States.
Anil KumarDepartment of Chemistry, Oakland University, 146 Library Drive, Rochester, Michigan 48309, United States.ORCID 0000-0002-9979-7798
Michael D SevillaDepartment of Chemistry, Oakland University, 146 Library Drive, Rochester, Michigan 48309, United States.ORCID 0000-0001-8799-5458
Stanislaw F WnukDepartment of Chemistry and Biochemistry, Florida International University, Miami, Florida 33199, United States.ORCID 0000-0002-3111-3919
Amitava AdhikaryDepartment of Chemistry, Oakland University, 146 Library Drive, Rochester, Michigan 48309, United States.ORCID 0000-0001-9024-9579
Oakland University · USFlorida International University · US

Funding

RADIOPROTECTION OF DNA BY THIOLS--OXYGEN AND LET EFFECTSR01CA045424 · NCI · OAKLAND UNIVERSITY · PI SEVILLA, MICHAEL DOUGLAS · 1987 to 2021
$4.2M
Nucleoside and Carbohydrate-based Enzyme InhibitorsSC1CA138176 · NCI · FLORIDA INTERNATIONAL UNIVERSITY · PI WNUK, STANISLAW F · 2008 to 2011
$818k
NCI NIH HHS R01 CA045424NCI NIH HHS SC1 CA138176
6 · The paper itself

Abstract

In this work, electron-induced site-specific formation of neutral π-type aminyl radicals (RNH·) and their reactions with pyrimidine nucleoside analogs azidolabeled at various positions in the sugar moiety, e.g., at 2'-, 3'-, 4'-, and 5'- sites along with a model compound 3-azido-1-propanol (3AZPrOH), were investigated. Electron paramagnetic resonance (EPR) studies confirmed the site and mechanism of RNH· formation via dissociative electron attachment-mediated loss of N

Indexed as

ElectronsNucleosidesElectron Spin Resonance SpectroscopyFree RadicalsPyrimidinesSugarsazidopyrimidineFree RadicalsNucleosidesPyrimidinesSugars

Identifiers

PMID33270461
PMCPMC7746630
OpenAlexW3106738678

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.