Evidence map›Paper›PMID 33270439›Full record

ArticleBiochemistry2020

An Aromatic Cluster in the Active Site of

Trey A Ronnebaum, Sarah M Gardner, David W Christianson

Abstract read
In one paragraph

Article in Biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Discovery, Structure, and Mechanism of a Class II Sesquiterpene Cyclase.Journal of the American Chemical Society · 2022
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Trey A RonnebaumRoy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States.ORCID 0000-0002-9214-3564
Sarah M GardnerDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0003-0697-4749
David W ChristiansonRoy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States.ORCID 0000-0002-0194-5212

Funding

X-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Sean McSweeney · 2019 to 2026
$38.6M
User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Nozomi Ando, J Christopher Fromme · 2018 to 2026
$34.2M
STRUCTURE/FUNCTION OF BIOSYNTHETIC ENZYMESR01GM056838 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI CHRISTIANSON, DAVID W · 1998 to 2025
$8.0M
Structural biology and molecular biophysics training programT32GM132039 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Ben E. Black, Elizabeth Rhoades · 2019 to 2026
$3.3M
Pixel Array Detector for X-ray CrystallographyS10RR029205 · NCRR · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2010 to 2010
$1.8M
Understanding Oligomer Assembly of Isoprenoid and Terpene SynthasesF32GM137461 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI RONNEBAUM, TREY ADAM · 2021 to 2022
$77k
NCRR NIH HHS S10 RR029205NIGMS NIH HHS F32 GM137461NIGMS NIH HHS P30 GM124165NIGMS NIH HHS P30 GM133893NIGMS NIH HHS R01 GM056838NIGMS NIH HHS T32 GM132039
6 · The paper itself

Abstract

The sesquiterpene cyclase

Indexed as

Bacterial ProteinsCarbon-Carbon LyasesCatalytic DomainCrystallography, X-RayCyclizationModels, MolecularMutagenesis, Site-DirectedProtein ConformationRecombinant ProteinsSesquiterpenesStatic ElectricityStereoisomerismStreptomyces coelicolorSubstrate SpecificityTerpenesWaterBacterial ProteinsCarbon-Carbon Lyasesepi-isozizaeneRecombinant ProteinsSesquiterpenesTerpenestrichodiene synthetaseWater

Identifiers

PMID33270439
PMCPMC8132545

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.