ReviewEuropean journal of haematology2021
The hematologic consequences of obesity.
Review in European journal of haematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05864079 (Serum Levels of Developmental Endothelial Locus-1 and Its Relationship With Platelet Count and Soluble P-selectin in Overweight and Obese Subjects), which is not on this map. Cited by 97 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Serum Levels of Developmental Endothelial Locus-1 and Its Relationship With Platelet Count and Soluble P-selectin in Overweight and Obese Subjects
Who cites it
97 citing papers in PubMed, 1 synthesis or guideline pooled it, 199 citations in OpenAlex.
- Hepcidin and inflammation associated with iron deficiency in childhood obesity - A systematic review.Jornal de pediatriaPooled it
- The Effect of Ultrasound-Guided Multipoint Thoracic Paravertebral Nerve Block in Metabolic and Bariatric Surgery (MBS): A Prospective Randomized Controlled Trial.Obesity surgery · 2025Trial
- Trial
- Obesity and Cardiovascular Disease: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2026.Obesity pillars · 2026Review
- When LXA4 meets white fat: browning via the miR-133a-3p/SIRT1 pathway in mouse models.Adipocyte · 2026Article
- Inflammatory Markers Associated with Antidepressant-Related Side Effects in Patients with Major Depressive Disorder: A Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Myrtle berry juice improves hematological parameters and alleviates oxidative stress and inflammation in the myocardium of rats fed a high-fat diet: A combined in vivo and in silico investigation.Journal of the science of food and agriculture · 2026Article
- Association of Early Postoperative Biochemical Markers with a Composite Adverse Perioperative Outcome After Bariatric Surgery.Diagnostics (Basel, Switzerland) · 2026Article
- Transfusion Practice in Elderly Surgical Patients in Germany-A Secondary Data Analysis of over 21 Million Patients over a Decade.Medicina (Kaunas, Lithuania) · 2026Article
- The role of the peripheral immune system in mediating axonal dysfunction in early-stage amyotrophic lateral sclerosis: An age- and sex-based analysis.Neural regeneration research · 2026Article
- Dendrobium officinale polysaccharide ameliorate hyperlipidemia through LKB1/AMPK and CD36/PGC-1α/UCP1 activation and gut microbiota modulation.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Hematological markers of proinflammatory and prothrombotic states in normal-weight obesity (NWO).Scientific reports · 2026Article
- Maternal Obesity Modulates Postpartum Inflammatory and Hormonal Profiles, Without Detectable Differences in Tested Redox Markers.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Observational
- Identification of a novel long non-coding RNA (LOC105377284) regulating PPARγ-dependent adipogenesis.Molecular biology reports · 2026Article
- Article
- Tissue-Specific Multi-Omics Integration Demonstrates Molecular Signatures Connecting Obesity to Immune Vulnerability.Metabolites · 2026Article
- Impact of a soybean oil-enriched diet on metabolic parameters in a chick model of childhood obesity.Veterinary research forum : an international quarterly journal · 2026Article
- A defined multi-metabolite formulation derived from Salvia miltiorrhiza alleviates obesity-associated cardiac lipotoxicity via modulating mitochondrial dynamics.Frontiers in pharmacology · 2026Article
- Causal effects of maternal BMI on pregnancy outcomes: a Mendelian randomisation study investigating the mediating role of blood counts.Frontiers in genetics · 2026Article
- Relationship between myeloid skewing and colorectal cancer risk in the Framingham Heart Study.Frontiers in oncology · 2026Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The prevalence of obesity is increasing and progressively influencing physician-patient interactions. While there is a sizable amount of data demonstrating that obesity is a state of low-grade inflammation, to our knowledge, there is no single review summarizing its effects on hematologic parameters and thrombotic risk. We performed a literature search which largely surfaced observational studies, with a few systematic reviews and meta-analyses of these studies. We took care to review the mechanisms driving an inflammatory state and obesity's effect on white blood cells, red blood cells, platelets, and thrombotic risk. There is an observed relative, and sometimes absolute leukocytosis driven by this inflammatory state. Obesity is also associated with increased platelet counts and an increased risk for venous thromboembolism (VTE). Lastly, the association between obesity, iron deficiency (ID), and red blood cell counts may be present but remains uncertain. Recognizing the above associations may provide clinicians with reassurance regarding otherwise unexplained hematologic abnormalities in obese individuals. We hope this review will prompt future studies to further understand the underlying mechanisms driving these abnormalities and identify modifiable risk factors and potential therapeutic targets to prevent the development of probable obesity-associated conditions with significant morbidity and mortality, such as ID and VTE.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.