Evidence map›Paper›PMID 33270134›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2021

Absence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Activity in Prepandemic Sera From Individuals With Recent Seasonal Coronavirus Infection.

Daniel Poston, Yiska Weisblum, Helen Wise, Kate Templeton, Sara Jenks, Theodora Hatziioannou, Paul Bieniasz

Abstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed.

  1. Trial
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  9. Human coronavirus OC43-elicited CD4Nature communications · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Daniel PostonLaboratory of Retrovirology, The Rockefeller University, New York, NY, USA.
Yiska WeisblumLaboratory of Retrovirology, The Rockefeller University, New York, NY, USA.
Helen WiseRoyal Infirmary of Edinburgh, NHS Lothian, Edinburgh, United Kingdom.
Kate TempletonRoyal Infirmary of Edinburgh, NHS Lothian, Edinburgh, United Kingdom.
Sara JenksRoyal Infirmary of Edinburgh, NHS Lothian, Edinburgh, United Kingdom.
Theodora HatziioannouLaboratory of Retrovirology, The Rockefeller University, New York, NY, USA.
Paul BieniaszLaboratory of Retrovirology, The Rockefeller University, New York, NY, USA.ORCID 0000-0002-2368-3719

Funding

Weill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1M
Overcoming Host Restriction Factors to Develop Better Animal Models for HIV/AIDS.R01AI078788 · NIAID · ROCKEFELLER UNIVERSITY · PI HATZIIOANNOU, THEODORA · 2008 to 2021
$9.3M
Elucidating antiviral defenses against diverse immunodeficiency viruses using a novel, high-throughput CRISPR/Cas9 screening method.F30AI157898 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI POSTON, DANIEL · 2021 to 2024
$191k
National Institute of Allergy and Infectious Diseases R37AI640003NIAID NIH HHS F30 AI157898NIAID NIH HHS R01 AI078788NIGMS NIH HHS T32 GM007739NIH HHS T32GM007739
6 · The paper itself

Abstract

Cross-reactive immune responses elicited by seasonal coronaviruses might affect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) susceptibility and disease outcomes. We measured neutralizing activity against SARS-CoV-2 in prepandemic sera from patients with prior polymerase chain reaction scan-confirmed seasonal coronavirus infection. Although neutralizing activity against seasonal coronaviruses was detected in nearly all sera, cross-reactive neutralizing activity against SARS-CoV-2 was undetectable.

Indexed as

antibodiesCOVID-19neutralizationSARS-CoV-2seasonal coronavirus

Identifiers

PMID33270134
PMCPMC7799301

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.