Evidence map›Paper›PMID 33270017›Full record

ArticleeLife2020

BAD inactivation exacerbates rheumatoid arthritis pathology by promoting survival of sublining macrophages.

Jie Li, Liansheng Zhang, Yongwei Zheng, Rui Shao, Qianqian Liang, Weida Yu, Hongyan Wang, Weiguo Zou, Demin Wang, Jialing Xiang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  4. Review
  5. Engineered Extracellular Vesicle-Delivered CRISPR/CasRx as a Novel RNA Editing Tool.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Jie Li *The State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai, China.ORCID 0000-0002-5446-894X
Liansheng Zhang *The State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai, China.ORCID 0000-0001-6444-6421
Yongwei ZhengBlood Research Institute, Blood Center of Wisconsin, Milwaukee, United States.
Rui ShaoThe State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai, China.
Qianqian LiangDepartment of Orthopaedics, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Weida YuThe State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai, China.
Hongyan WangThe State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai, China.
Weiguo ZouThe State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai, China.ORCID 0000-0003-2516-0302
Demin WangBlood Research Institute, Blood Center of Wisconsin, Milwaukee, United States.
Jialing XiangDepartment of Biology, Illinois Institute of Technology, Chicago, United States.
Anning LinBen May Department for Cancer Research, The University of Chicago, Chicago, United States.ORCID 0000-0003-2754-5134
Center for Excellence in Molecular Cell Science · CNShanghaiTech University · CNUniversity of Chicago · USVersiti Blood Center of Wisconsin · USIllinois Institute of Technology · USShanghai University of Traditional Chinese Medicine · CN

Funding

B cell responses in heparin-induced thrombocytopeniaR01HL130724 · NHLBI · VERSITI WISCONSIN, INC. · PI WANG, DEMIN · 2017 to 2024
$4.8M
PLC?s in B cell biology and autoimmunityR01AI079087 · NIAID · VERSITI WISCONSIN, INC. · PI WANG, DEMIN · 2008 to 2018
$4.4M
Mechanism of IKK Signaling NetworkR01GM103868 · NIGMS · UNIVERSITY OF CHICAGO · PI LIN, ANNING · 2013 to 2016
$1.2M
Mechanism and Regulation of Baxdelta2 in Colorectal CancerR15CA195526 · NCI · ILLINOIS INSTITUTE OF TECHNOLOGY · PI XIANG, JIALING · 2016 to 2016
$458k
NCI NIH HHS R15 CA195526NHLBI NIH HHS R01 HL130724NIAID NIH HHS R01 AI079087NIGMS NIH HHS R01 GM103868NIH HHS AI079087NIH HHS CA195526NIH HHS GM103868NIH HHS HL130724
6 · The paper itself

Abstract

The resistance of synovial sublining macrophages to apoptosis has a crucial role in joint inflammation and destruction in rheumatoid arthritis (RA). However, the underlying mechanism is incompletely understood. Here we report that inactivation of the pro-apoptotic BCL-2 family protein BAD is essential for survival of synovial sublining macrophage in RA. Genetic disruption of

Indexed as

AdultAgedAnimalsArthritis, Rheumatoidbcl-Associated Death ProteinBone Marrow TransplantationCollagenFemaleHumansMacrophagesMaleMiceMice, KnockoutMiddle AgedOsteoarthritisBAD protein, humanBad protein, mousebcl-Associated Death ProteinCollagenapoptosisBADhumanimmunologyinflammationmacrophagesmouserheumatoid arthritis

Identifiers

PMID33270017
PMCPMC7714394
OpenAlexW3107920200

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.