Evidence map›Paper›PMID 33269912›Full record

ArticleACS infectious diseases2021

Small Molecule Inhibitors of the Bacterioferritin (BfrB)-Ferredoxin (Bfd) Complex Kill Biofilm-Embedded

Anabel Soldano, Huili Yao, Achala N D Punchi Hewage, Kevin Meraz, Joel K Annor-Gyamfi, Richard A Bunce, Kevin P Battaile, Scott Lovell, Mario Rivera

Open access · hybridAbstract read
In one paragraph

Article in ACS infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Protein-centric mechanisms of typhoidalFrontiers in cellular and infection microbiology · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Frontiers in molecular biosciences · 2024
    Article
  13. Review
  14. Review
  15. Article
  16. International journal of molecular sciences · 2023
    Article
  17. Article
  18. Biomolecules · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Anabel SoldanoDepartment of Chemistry, Louisiana State University, 232 Choppin Hall, Baton Rouge, Louisiana 70803, United States.
Huili YaoDepartment of Chemistry, Louisiana State University, 232 Choppin Hall, Baton Rouge, Louisiana 70803, United States.
Achala N D Punchi HewageDepartment of Chemistry, University of Kansas, 2030 Becker Drive, Lawrence, Kansas 66047, United States.
Kevin MerazDepartment of Chemistry, Oklahoma State University, Stillwater, Oklahoma 74078, United States.
Joel K Annor-GyamfiDepartment of Chemistry, Oklahoma State University, Stillwater, Oklahoma 74078, United States.
Richard A BunceDepartment of Chemistry, Oklahoma State University, Stillwater, Oklahoma 74078, United States.
Kevin P BattaileNYX, New York Structural Biology Center, Upton, New York 11973, United States.ORCID 0000-0003-0833-3259
Scott LovellProtein Structure Laboratory, University of Kansas, 2034 Becker Drive, Lawrence, Kansas 66047, United States.
Mario RiveraDepartment of Chemistry, Louisiana State University, 232 Choppin Hall, Baton Rouge, Louisiana 70803, United States.ORCID 0000-0002-5692-5497
Louisiana State University · USOklahoma State University · USUniversity of Kansas · USNew York Structural Biology Center · US

Funding

Small molecules for perturbing iron homeostasis in bacterial biofilmsR01AI169344 · NIAID · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI Mario Rivera · 2022 to 2026
$3.7M
Chemical tools for perturbing iron homeostasis in P. aeruginosaR01AI125529 · NIAID · UNIVERSITY OF KANSAS LAWRENCE · PI RIVERA, MARIO · 2016 to 2019
$1.4M
NIAID NIH HHS R01 AI125529NIAID NIH HHS R01 AI169344
6 · The paper itself

Abstract

Bacteria depend on a well-regulated iron homeostasis to survive adverse environments. A key component of the iron homeostasis machinery is the compartmentalization of Fe

Indexed as

FerredoxinsPseudomonas aeruginosaBacterial ProteinsBiofilmsCrystallography, X-RayCytochrome b GroupFerritinsBacterial ProteinsbacterioferritinCytochrome b GroupFerredoxinsFerritinsbacterioferritinbiofilmiron homeostasisiron metabolismPseudomonas aeruginosa

Identifiers

PMID33269912
PMCPMC7802073
OpenAlexW3109239045

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.