ArticleSchizophrenia bulletin2021
Epigenetic Age Acceleration Was Delayed in Schizophrenia.
Article in Schizophrenia bulletin, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- A perspective on epigenomic aging processes in the human brain and their plasticity in patients with mental disorders - a systematic review.Neurogenetics · 2024Pooled it
- Meta-analysis of epigenetic aging in schizophrenia reveals multifaceted relationships with age, sex, illness duration, and polygenic risk.Clinical epigenetics · 2024Pooled it
- Article
- Replicated evidence for an accelerated rate of whole-body aging in schizophrenia.Psychological medicine · 2026Article
- The Emerging Role of the DDAH Proteins in Psychiatric Disorders.Biological psychiatry global open science · 2025Review
- Glucocorticoid exposure-induced alterations in epigenetic age from human preterm infants and human lung fibroblasts and hippocampal neuronal cells.Clinical epigenetics · 2025Article
- Causal association of epigenetic age acceleration and risk of subacute thyroiditis: a bidirectional Mendelian randomization study.Clinical epigenetics · 2024Article
- Accelerated Pace of Aging in Schizophrenia: Five Case-Control Studies.Biological psychiatry · 2024Article
- Polygenic risk for schizophrenia, social dispositions, and pace of epigenetic aging: Results from the Young Finns Study.Aging cell · 2024Article
- Examining epigenetic aging in the post-mortem brain in attention deficit hyperactivity disorder.Frontiers in genetics · 2024Article
- The Cutting Edge of Epigenetic Clocks: In Search of Mechanisms Linking Aging and Mental Health.Biological psychiatry · 2023Review
- DNMT1 SNPs (rs2114724 and rs2228611) associated with positive symptoms in Chinese patients with schizophrenia.Annals of general psychiatry · 2023Article
- Epigenetic age deacceleration in youth at familial risk for schizophrenia and bipolar disorder.Translational psychiatry · 2023Article
- Epigenetic clock analysis of blood samples in drug-naive first-episode schizophrenia patients.BMC psychiatry · 2023Article
- Subjective Overview of Accelerated Aging in Schizophrenia.International journal of environmental research and public health · 2022Review
- Epigenome-wide DNA methylation analysis of whole blood cells derived from patients with GAD and OCD in the Chinese Han population.Translational psychiatry · 2022Article
- Assessment of DDAH1 and DDAH2 Contributions to Psychiatric Disorders via In Silico Methods.International journal of molecular sciences · 2022Article
- Antipsychotics function as epigenetic age regulators in human neuroblastoma cells.Schizophrenia (Heidelberg, Germany) · 2022Article
- Epigenetic clocks in relapse after a first episode of schizophrenia.Schizophrenia (Heidelberg, Germany) · 2022Article
- Dysmaturational Longitudinal Epigenetic Aging During Transition to Psychosis.Schizophrenia bulletin open · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia is a serious neuropsychiatric disorder with abnormal age-related neurodevelopmental (or neurodegenerative) trajectories. Although an accelerated aging hypothesis of schizophrenia has been proposed, the quantitative study of the disruption of the physiological trajectory caused by schizophrenia is inconclusive. In this study, we employed 3 "epigenetic clock" methods to quantify the epigenetic age of a large sample size of whole blood (1069 samples from patients with schizophrenia vs 1264 samples from unaffected controls) and brain tissues (500 samples from patients with schizophrenia vs 711 samples from unaffected controls). We observed significant positive correlations between epigenetic age and chronological age in both blood and brain tissues from unaffected controls and patients with schizophrenia, as estimated by 3 methods. Furthermore, we observed that epigenetic age acceleration was significantly delayed in schizophrenia from the whole blood samples (aged 20-90 years) and brain frontal cortex tissues (aged 20-39 years). Intriguingly, the genes regulated by the epigenetic clock also contained schizophrenia-associated genes, displaying differential expression and methylation in patients with schizophrenia and involving in the regulation of cell activation and development. These findings were further supported by the dysregulated leukocyte composition in patients with schizophrenia. Our study presents quantitative evidence for a neurodevelopmental model of schizophrenia from the perspective of a skewed "epigenetic clock." Moreover, landmark changes in an easily accessible biological sample, blood, reveal the value of these epigenetic clock genes as peripheral biomarkers for schizophrenia.
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