ArticleMicrobiologyOpen2021
Pantoea ananatis carotenoid production confers toxoflavin tolerance and is regulated by Hfq-controlled quorum sensing.
Article in MicrobiologyOpen, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 25 citations in OpenAlex.
- Comparative genomics ofMicrobial genomics · 2026Article
- Plasmids encode and can mobilize onion pathogenicity in Pantoea agglomerans.The ISME journal · 2025Article
- Exploration of carotenoid-producingCurrent research in microbial sciences · 2025Article
- Radiotolerant endophytic bacteria and analysis of the effects ofBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Review
- Comparative Genomic and Functional Analyses for Insights into Pantoea agglomerans Strains Adaptability in Diverse Ecological Niches.Current microbiology · 2024Article
- Comparative genomics of a novelMicrobial genomics · 2024Article
- RpoS-Regulated Genes and Phenotypes in the Phytopathogenic BacteriumInternational journal of molecular sciences · 2023Article
- Draft genome sequences ofMicrobiology resource announcements · 2023Article
- Quorum-quenching potential of recombinant PvdQ-engineered bacteria for biofilm formation.International microbiology : the official journal of the Spanish Society for Microbiology · 2023Article
- Herbicolin A production and its modulation by quorum sensing in a Pantoea agglomerans rhizobacterium bioactive against a broad spectrum of plant-pathogenic fungi.Microbial biotechnology · 2023Article
- Article
- Screening and evaluation of skin potential probiotic from high-altitude Tibetans to repair ultraviolet radiation damage.Frontiers in microbiology · 2023Article
- Negatively Regulated Aerobactin and Desferrioxamine E by Fur in Pantoea ananatis Are Required for Full Siderophore Production and Antibacterial Activity, but Not for Virulence.Applied and environmental microbiology · 2022Article
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Authors and funding
5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Carotenoids are widely used in functional foods, cosmetics, and health supplements, and their importance and scope of use are continuously expanding. Here, we characterized carotenoid biosynthetic genes of the plant-pathogenic bacterium Pantoea ananatis, which carries a carotenoid biosynthetic gene cluster (including crtE, X, Y, I, B, and Z) on a plasmid. Reverse transcription-polymerase chain reaction (RT-PCR) analysis revealed that the crtEXYIB gene cluster is transcribed as a single transcript and crtZ is independently transcribed in the opposite direction. Using splicing by overlap extension with polymerase chain reaction (SOE by PCR) based on asymmetric amplification, we reassembled crtE-B, crtE-B-I, and crtE-B-I-Y. High-performance liquid chromatography confirmed that Escherichia coli expressing the reassembled crtE-B, crtE-B-I, and crtE-B-I-Y operons produced phytoene, lycopene, and β-carotene, respectively. We found that the carotenoids conferred tolerance to UV radiation and toxoflavin. Pantoea ananatis shares rice environments with the toxoflavin producer Burkholderia glumae and is considered to be the first reported example of producing and using carotenoids to withstand toxoflavin. We confirmed that carotenoid production by P. ananatis depends on RpoS, which is positively regulated by Hfq/ArcZ and negatively regulated by ClpP, similar to an important regulatory network of E. coli (Hfq
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