Evidence map›Paper›PMID 33269475›Full record

ArticleJournal of applied toxicology : JAT2021

Biodistribution, cardiac and neurobehavioral assessments, and neurotransmitter quantification in juvenile rats following oral administration of aluminum oxide nanoparticles.

Ninell P Mortensen, Maria Moreno Caffaro, Purvi R Patel, Rodney W Snyder, Scott L Watson, Shyam Aravamudhan, Stephanie A Montgomery, Timothy Lefever, Susan J Sumner, Timothy R Fennell

Open access · greenAbstract read
In one paragraph

Article in Journal of applied toxicology : JAT, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Oral administration of TiOParticle and fibre toxicology · 2022
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Ninell P MortensenDiscovery Sciences, RTI International, Research Triangle Park, North Carolina, USA.ORCID 0000-0001-7980-8958
Maria Moreno CaffaroDiscovery Sciences, RTI International, Research Triangle Park, North Carolina, USA.
Purvi R PatelDiscovery Sciences, RTI International, Research Triangle Park, North Carolina, USA.
Rodney W SnyderDiscovery Sciences, RTI International, Research Triangle Park, North Carolina, USA.
Scott L WatsonDiscovery Sciences, RTI International, Research Triangle Park, North Carolina, USA.
Shyam AravamudhanJoint School of Nanoscience and Nanoengineering, North Carolina A&T State University, Greensboro, North Carolina, USA.
Stephanie A MontgomeryDepartment of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Timothy LefeverDiscovery Sciences, RTI International, Research Triangle Park, North Carolina, USA.
Susan J SumnerUNC Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina, USA.
Timothy R FennellDiscovery Sciences, RTI International, Research Triangle Park, North Carolina, USA.
RTI International · USUniversity of North Carolina at Chapel Hill · USNorth Carolina Agricultural and Technical State University · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5M
Engineered Nanomaterial Synthesis, Characterization and Method Development Center for Nano-safety ResearchU24ES026946 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI DEMOKRITOU, PHILIP · 2016 to 2020
$3.8M
Early life ENM-exposure and the impact on neurobehavioral and cardiovascular outcomes and biochemical mechanismsU01ES027254 · NIEHS · RESEARCH TRIANGLE INSTITUTE · PI FENNELL, TIMOTHY RAYMOND, SUMNER, SUSAN J · 2016 to 2020
$2.6M
NCI NIH HHS P30 CA016086NIEHS NIH HHS U01 ES027254NIEHS NIH HHS U24 ES026946
6 · The paper itself

Abstract

Little is known about the uptake, biodistribution, and biological responses of nanoparticles (NPs) and their toxicity in developing animals. Here, male and female juvenile Sprague-Dawley rats received four consecutive daily doses of 10 mg/kg Al

Indexed as

Administration, OralAluminum OxideAnimalsBrainElectrocardiographyFemaleHeartMaleMetal NanoparticlesMotor ActivityNeurotransmitter AgentsRatsRats, Sprague-DawleyRotarod Performance TestTissue DistributionAluminum OxideNeurotransmitter AgentsAl2O3 nanoparticlesbiodistributionbrain biochemistrycardiac assessmentgut-brain axisjuvenile ratsneurobehavioral assessmentneurotransmitters

Identifiers

PMID33269475
PMCPMC8169715
OpenAlexW3106567861

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.