Evidence map›Paper›PMID 33269432›Full record

ArticleMolecular biology reports2020

TRAILR1 (rs20576) and GRIA3 (rs12557782) are not associated with interferon-β response in multiple sclerosis patients.

Parham Jazireian, Soheila Talesh Sasani, Farhad Assarzadegan, Mojtaba Azimian

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In one paragraph

Article in Molecular biology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Parham JazireianDepartment of Biology, University Campus 2, University of Guilan, Rasht, Iran.
Soheila Talesh SasaniDepartment of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran. sasani@guilan.ac.ir.ORCID https://orcid.org/0000-0002-4668-8555
Farhad AssarzadeganDepartment of Neurology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mojtaba AzimianRofeydeh Rehabilitation Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
University of Guilan · IRImam Hossein Hospital · IRUniversity of Social Welfare and Rehabilitation Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis (MS) is an autoimmune-type inflammatory disorder in human central nervous system. Recombinant interferon beta (IFN-β) decreases the number of relapses and postpones disability progression in MS. However, up to 50% of patients treated with interferon beta continue experiencing relapses and/or worsening disability. Single nucleotide polymorphisms in different genes have been known to show significant associations with response to IFN-β in MS patients. In the present work, we examined the potential role of TRAILR1 and GRIA3 genes polymorphisms on response to IFN-β therapy in Iranian MS patients. The DNA was extracted from blood samples by standard procedures from 73 patients diagnosed with Multiple Sclerosis that were either responded to IFN-β or did not. We carried out RFLP -PCR and tetra-primer ARMS-PCR methods to study of rs20576 and rs12557782, respectively. All results were analyzed using the SPSS software. TRAILR1 rs20576 genotype frequencies in responders and non-responders were similar (χ

Indexed as

Polymorphism, Single NucleotideAdolescentAdultFemaleGenetic Association StudiesGenotypeHumansImmunologic FactorsInterferon-betaMaleMultiple Sclerosis, Relapsing-RemittingPharmacogeneticsPolymorphism, Restriction Fragment LengthReceptor Activator of Nuclear Factor-kappa BReceptors, AMPARecombinant Proteinsglutamate receptor ionotropic, AMPA 3Immunologic FactorsInterferon-betaReceptor Activator of Nuclear Factor-kappa BReceptors, AMPARecombinant ProteinsTNFRSF11A protein, humanGene polymorphismsInterferon-βMultiple sclerosisPharmacogenetics

Identifiers

PMID33269432
OpenAlexW3109373406

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.