Evidence map›Paper›PMID 33269402›Full record

ArticleThe Journal of infectious diseases2022

Risk Factors for Ebola Exposure in Health Care Workers in Boende, Tshuapa Province, Democratic Republic of the Congo.

Reena H Doshi, Nicole A Hoff, Anna Bratcher, Patrick Mukadi, Adva Gadoth, Bradly P Nicholson, Russell Williams, Daniel Mukadi, Matthias Mossoko, Joseph Wasiswa and 9 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.2field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 2 countries.

Reena H DoshiDepartment of Epidemiology, University of California Los Angeles, Fielding School of Public Health, Los Angeles, California, USA.
Nicole A HoffDepartment of Epidemiology, University of California Los Angeles, Fielding School of Public Health, Los Angeles, California, USA.
Anna BratcherDepartment of Epidemiology, University of California Los Angeles, Fielding School of Public Health, Los Angeles, California, USA.
Patrick MukadiInstitut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo.
Adva GadothDepartment of Epidemiology, University of California Los Angeles, Fielding School of Public Health, Los Angeles, California, USA.
Bradly P NicholsonInstitue for Medical Research, Veterans Affairs Medical Center, Durham, North Carolina, USA.
Russell WilliamsUniversity of California Los Angeles-Democratic Republic of the Congo Research Program, Kinshasa, Democratic Republic of the Congo.
Daniel MukadiInstitut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo.
Matthias MossokoDirection de Lutte Contre la Maladie, Ministère de la Santé Publique, Kinshasa, Democratic Republic of the Congo.
Joseph WasiswaUniversity of California Los Angeles-Democratic Republic of the Congo Research Program, Kinshasa, Democratic Republic of the Congo.
Alexis MwanzaUniversity of California Los Angeles-Democratic Republic of the Congo Research Program, Kinshasa, Democratic Republic of the Congo.
Cyrus SinaiDepartment of Epidemiology, University of California Los Angeles, Fielding School of Public Health, Los Angeles, California, USA.
Vivian H AlfonsoDepartment of Epidemiology, University of California Los Angeles, Fielding School of Public Health, Los Angeles, California, USA.
Rupal ShahDepartment of Epidemiology, University of California Los Angeles, Fielding School of Public Health, Los Angeles, California, USA.
Matthew S BrambleDepartment of Genetic Medicine Research, Children's Research Institute, Children's National Medical Center, Washington, District of Columbia, USA.
Benoit Ilunga-KebelaDirection de Lutte Contre la Maladie, Ministère de la Santé Publique, Kinshasa, Democratic Republic of the Congo.
Emile Okitolonda-WemakoyEcole de Sante Publique, Université de Kinshasa, Kinshasa, Democratic Republic of the Congo.
Jean Jacques Muyembe-TamfumInstitut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo.
Anne W RimoinDepartment of Epidemiology, University of California Los Angeles, Fielding School of Public Health, Los Angeles, California, USA.
University of California, Los Angeles · USMinistry of Public Health · CDUniversity of Kinshasa · CDNational Institute of Biomedical Research · CDChildren's National · USDurham VA Medical Center · US

Funding

University of California Launching Future Leaders in Global Health Research Training ProgramD43TW009343 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CRAIG R COHEN, Sung-Jae Lee · 2017 to 2026
$14.7M
FIC NIH HHS D43 TW009343
6 · The paper itself

Abstract

backgroundHealth care workers (HCW) are more likely to be exposed to Ebola virus (EBOV) during an outbreak compared to people in the general population due to close physical contact with patients and potential exposure to infectious fluids. However, not all will fall ill. Despite evidence of subclinical and paucisymptomatic Ebola virus disease (EVD), prevalence and associated risk factors remain unknown.

methodsWe conducted a serosurvey among HCW in Boende, Tshuapa Province, Democratic Republic of Congo. Human anti-EBOV glycoprotein IgG titers were measured using a commercially available ELISA kit. We assessed associations between anti-EBOV IgG seroreactivity, defined as ≥2.5 units/mL, and risk factors using univariable and multivariable logistic regression. Sensitivity analyses explored a more conservative cutoff, >5 units/mL.

resultsOverall, 22.5% of HCWs were seroreactive for EBOV. In multivariable analyses, using any form of personal protective equipment when interacting with a confirmed, probable, or suspect EVD case was negatively associated with seroreactivity (adjusted odds ratio, 0.23; 95% confidence interval, .07-.73). DISCUSSION: Our results suggest high exposure to EBOV among HCWs and provide additional evidence for asymptomatic or minimally symptomatic EVD. Further studies should be conducted to determine the probability of onward transmission and if seroreactivity is associated with immunity.

Indexed as

EbolavirusHemorrhagic Fever, EbolaDemocratic Republic of the CongoDisease OutbreaksHealth PersonnelHumansImmunoglobulin GRisk FactorsImmunoglobulin GDemocratic Republic of the CongoEbolahealth care workersrisk factors

Identifiers

PMID33269402
PMCPMC9441197
OpenAlexW3108809025

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.