Evidence map›Paper›PMID 33269350›Full record

ArticlebioRxiv : the preprint server for biology2021

Ipomoeassin-F inhibits the

Sarah O'Keefe, Peristera Roboti, Kwabena B Duah, Guanghui Zong, Hayden Schneider, Wei Q Shi, Stephen High

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Sarah O'KeefeSchool of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PT, United Kingdom.
Peristera RobotiSchool of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PT, United Kingdom.
Kwabena B DuahDepartment of Chemistry, Ball State University, Muncie, Indiana 47306, USA.
Guanghui ZongDepartment of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, USA.
Hayden SchneiderDepartment of Chemistry, Ball State University, Muncie, Indiana 47306, USA.
Wei Q ShiDepartment of Chemistry, Ball State University, Muncie, Indiana 47306, USA.
Stephen HighSchool of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PT, United Kingdom.
Ball State University · USUniversity of Manchester · GBUniversity of Maryland, College Park · US

Funding

Medicinal Chemistry and Chemical Proteomics of Ipomoeassin Natural GlycoresinsR15GM116032 · NIGMS · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI SHI, WEI · 2015 to 2020
$767k
NIGMS NIH HHS R15 GM116032Wellcome Trust
6 · The paper itself

Abstract

In order to produce proteins essential for their propagation, many pathogenic human viruses, including SARS-CoV-2 the causative agent of COVID-19 respiratory disease, commandeer host biosynthetic machineries and mechanisms. Three major structural proteins, the spike, envelope and membrane proteins, are amongst several SARS-CoV-2 components synthesised at the endoplasmic reticulum (ER) of infected human cells prior to the assembly of new viral particles. Hence, the inhibition of membrane protein synthesis at the ER is an attractive strategy for reducing the pathogenicity of SARS-CoV-2 and other obligate viral pathogens. Using an

Indexed as

Cell-free translationEndoplasmic reticulum (ER)ER membrane complex (EMC)Sec61 transloconviral protein biogenesis

Identifiers

PMID33269350
PMCPMC7709170
OpenAlexW3108194821

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.