Evidence map›Paper›PMID 33269329›Full record

ArticleACS central science2020

The SARS-COV-2 Spike Protein Binds Sialic Acids and Enables Rapid Detection in a Lateral Flow Point of Care Diagnostic Device.

Alexander N Baker, Sarah-Jane Richards, Collette S Guy, Thomas R Congdon, Muhammad Hasan, Alexander J Zwetsloot, Angelo Gallo, Józef R Lewandowski, Phillip J Stansfeld, Anne Straube and 6 more

Erratum issuedOpen access · diamondAbstract read
In one paragraph

Article in ACS central science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 149 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
149citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

149 citing papers in PubMed, 1 synthesis or guideline pooled it, 307 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Virus-Mediated Self-Assembly of Functional Cyclodextrins for Antiviral Inhibition.Angewandte Chemie (International ed. in English) · 2026
    Article
  5. Carbohydrate-based biosensors for enhanced pathogen detection.Analytical and bioanalytical chemistry · 2026
    Review
  6. Host Glycan-Lectin Interplay in SARS-CoV-2 Infection.International journal of molecular sciences · 2026
    Review
  7. Review
  8. ACS central science · 2025
    Article
  9. Article
  10. Polysialosides Outperform Sulfated Analogs for Binding with SARS-CoV-2.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

89 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Alexander N BakerDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, U.K.
Sarah-Jane RichardsDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, U.K.
Collette S GuyDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, U.K.
Thomas R CongdonDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, U.K.
Muhammad HasanDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, U.K.
Alexander J ZwetslootWarwick Medical School, University of Warwick, Coventry, CV4 7AL, U.K.
Angelo GalloDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, U.K.
Józef R LewandowskiDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, U.K.
Phillip J StansfeldDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, U.K.
Anne StraubeWarwick Medical School, University of Warwick, Coventry, CV4 7AL, U.K.
Marc WalkerDepartment of Physics, University of Warwick, Coventry, CV4 7AL, U.K.
Simona ChessaIceni Diagnostics Ltd, Norwich Research Park, Norwich, NR4 7GJ, U.K.
Giulia PergolizziIceni Diagnostics Ltd, Norwich Research Park, Norwich, NR4 7GJ, U.K.
Simone DedolaIceni Diagnostics Ltd, Norwich Research Park, Norwich, NR4 7GJ, U.K.
Robert A FieldIceni Diagnostics Ltd, Norwich Research Park, Norwich, NR4 7GJ, U.K.
Matthew I GibsonDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, U.K.
University of Warwick · GBNorwich Research Park · GB

Funding

European Research Council 638661Medical Research Council MR/S009213/1Wellcome Trust 200870/Z/16/Z
6 · The paper itself

Abstract

There is an urgent need to understand the behavior of the novel coronavirus (SARS-COV-2), which is the causative agent of COVID-19, and to develop point-of-care diagnostics. Here, a glyconanoparticle platform is used to discover that

Identifiers

PMID33269329
PMCPMC7523238
OpenAlexW3087144526

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.