Evidence map›Paper›PMID 33268955›Full record

SynthesisWorld journal of gastroenterology2020

Prognostic role of artificial intelligence among patients with hepatocellular cancer: A systematic review.

Quirino Lai, Gabriele Spoletini, Gianluca Mennini, Zoe Larghi Laureiro, Diamantis I Tsilimigras, Timothy Michael Pawlik, Massimo Rossi

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in World journal of gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. BMC cancer · 2025
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  10. BMC cancer · 2024
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  15. Article
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  19. A nomogram based on 4-lncRNAs signature for improving prognostic prediction of hepatocellular carcinoma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Quirino LaiHepato-biliary and Organ Transplant Unit, Department of Surgery, Sapienza University of Rome, Rome 00161, Italy. quirino.lai@uniroma1.it.
Gabriele SpoletiniGeneral Surgery and Liver Transplantation Unit, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome 00100, Italy.
Gianluca MenniniHepato-biliary and Organ Transplant Unit, Department of Surgery, Sapienza University of Rome, Rome 00161, Italy.
Zoe Larghi LaureiroHepato-biliary and Organ Transplant Unit, Department of Surgery, Sapienza University of Rome, Rome 00161, Italy.
Diamantis I TsilimigrasWexner Medical Center, The Ohio State University, Columbus, OH 43210, United States.
Timothy Michael PawlikWexner Medical Center, The Ohio State University, Columbus, OH 43210, United States.
Massimo RossiHepato-biliary and Organ Transplant Unit, Department of Surgery, Sapienza University of Rome, Rome 00161, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrediction of survival after the treatment of hepatocellular carcinoma (HCC) has been widely investigated, yet remains inadequate. The application of artificial intelligence (AI) is emerging as a valid adjunct to traditional statistics due to the ability to process vast amounts of data and find hidden interconnections between variables. AI and deep learning are increasingly employed in several topics of liver cancer research, including diagnosis, pathology, and prognosis.

aimTo assess the role of AI in the prediction of survival following HCC treatment.

methodsA web-based literature search was performed according to the Preferred Reporting Items for Systemic Reviews and Meta-Analysis guidelines using the keywords "artificial intelligence", "deep learning" and "hepatocellular carcinoma" (and synonyms). The specific research question was formulated following the patient (patients with HCC), intervention (evaluation of HCC treatment using AI), comparison (evaluation without using AI), and outcome (patient death and/or tumor recurrence) structure. English language articles were retrieved, screened, and reviewed by the authors. The quality of the papers was assessed using the Risk of Bias In Non-randomized Studies of Interventions tool. Data were extracted and collected in a database.

resultsAmong the 598 articles screened, nine papers met the inclusion criteria, six of which had low-risk rates of bias. Eight articles were published in the last decade; all came from eastern countries. Patient sample size was extremely heterogenous (

conclusionAI applied to survival prediction after HCC treatment provided enhanced accuracy compared with conventional linear systems of analysis. Improved transferability and reproducibility will facilitate the widespread use of AI methodologies.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsArtificial IntelligenceHumansNeoplasm Recurrence, LocalPrognosisReproducibility of ResultsArtificial neuronal networkDeep learningHepatocellular cancerLiver transplantationRecurrenceResection

Identifiers

PMID33268955
PMCPMC7673961

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.