ArticleNature2021
A brainstem peptide system activated at birth protects postnatal breathing.
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Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
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Who cites it
34 citing papers in PubMed, 56 citations in OpenAlex.
- Review of electroencephalography and electromyography research in robotics: opportunities and challenges.Visual computing for industry, biomedicine, and art · 2026Review
- Early Prediction of Delirium in Postcardiac Surgery Patients: Machine Learning Model Development and External Validation.JMIR medical informatics · 2026Article
- Tachykinergic signaling mediated by NK1 receptors in the respiratory parafacial region drives respiratory output and contributes to the chemoreflex response to COPflugers Archiv : European journal of physiology · 2026Article
- Disruption of Pre-Bötzinger Complex neuropeptidergic tonality controls fear and metabolic response.bioRxiv : the preprint server for biology · 2026Article
- Astrocytic Connexin43 Channels Are Essential for Breathing Pattern Stabilization in the preBötzinger Complex.CNS neuroscience & therapeutics · 2025Article
- Oxytocinergic signalling in the respiratory parafacial region increases the activity of chemosensitive neurons and respiratory output.The Journal of physiology · 2025Article
- Retrotrapezoid nucleus chemoreception: mechanisms of function and contributions to disordered breathing in disease.Trends in neurosciences · 2025Review
- Characterisation of putative retrotrapezoid nucleus (RTN) chemoreceptor neurons in the adult human brainstem.Brain structure & function · 2025Article
- The roles of feedback loops in the Caenorhabditis elegans rhythmic forward locomotion.PLoS computational biology · 2025Article
- A Molecularly Defined Medullary Network for Control of Respiratory Homeostasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Characterisation of sleep apneas and respiratory circuitry in mice lacking CDKL5.Journal of sleep research · 2025Article
- Sudden Unexpected Death in Epilepsy: Central Respiratory Chemoreception.International journal of molecular sciences · 2025Review
- Mechanosensitive channels TMEM63A and TMEM63B mediate lung inflation-induced surfactant secretion.The Journal of clinical investigation · 2024Article
- Personhood Begins at Birth: The Rational Foundation for Abortion Policy in a Secular State.Journal of bioethical inquiry · 2024Article
- Intrinsic Molecular Proton Sensitivity Underlies GPR4 Effects on Retrotrapezoid Nucleus Neuronal Activation and COThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Galaninergic and hypercapnia-activated neuronal projections to the ventral respiratory column.Brain structure & function · 2024Article
- Loss-of-function of chemoreceptor neurons in the retrotrapezoid nucleus: What have we learned from it?Respiratory physiology & neurobiology · 2024Article
- Article
- Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) and Sudden Infant Death Syndrome: A Potential Model for Investigation.International journal of molecular sciences · 2023Review
- Unexplained Significant Central Sleep Apnea in Infants: Clinical Presentation and Outcomes.Sleep & breathing = Schlaf & Atmung · 2023Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 2 countries.
Yingtang ShiDepartment of Pharmacology, University of Virginia, Charlottesville, VA, USA.
Daniel S StornettaDepartment of Pharmacology, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0002-5570-6276
Robert J ReklowDepartment of Physiology, Women & Children's Health Research Institute, Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada.
Alisha SahuDepartment of Pharmacology, University of Virginia, Charlottesville, VA, USA.
Yvonne WabaraDepartment of Pharmacology, University of Virginia, Charlottesville, VA, USA.
Ashley NguyenDepartment of Pharmacology, University of Virginia, Charlottesville, VA, USA.
Keyong LiDepartment of Pharmacology, University of Virginia, Charlottesville, VA, USA.
Yong ZhangDepartment of Physiology, Women & Children's Health Research Institute, Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada.
Edward Perez-ReyesDepartment of Pharmacology, University of Virginia, Charlottesville, VA, USA.
Rachel A RossBeth Israel Deaconess Medical Center, Harvard University, Boston, MA, USA.
Bradford B LowellBeth Israel Deaconess Medical Center, Harvard University, Boston, MA, USA.
Ruth L StornettaDepartment of Pharmacology, University of Virginia, Charlottesville, VA, USA.
Gregory D FunkDepartment of Physiology, Women & Children's Health Research Institute, Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada.ORCID http://orcid.org/0000-0001-5848-0631
Patrice G GuyenetDepartment of Pharmacology, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0003-1739-2306
Douglas A BaylissDepartment of Pharmacology, University of Virginia, Charlottesville, VA, USA. dab3y@virginia.edu.ORCID http://orcid.org/0000-0002-5630-2572
University of Virginia · USUniversity of Alberta · CABeth Israel Deaconess Medical Center · US
Funding
The routing of hunger/satiety information by the parabrachial nucleus (PBN)R01DK075632 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BRADFORD B LOWELL · 2006 to 2026
$8.1MTraining Program in Cardiovascular ResearchT32HL007374 · NHLBI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MITTLEMAN, MURRAY A · 1985 to 2019
$7.9MAGRP NEURONS. NMDARs, Spines, Source of Excitatory Input and Downstream EffectorsR01DK096010 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LOWELL, BRADFORD B · 2012 to 2024
$7.2MRetrotrapezoid nucleus and central chemoreceptionR01HL074011 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GUYENET, PATRICE G. · 2003 to 2018
$6.6MCellular/Molecular Mechanisms of Respiratory Neuronal ChemosensitivityR01HL108609 · NHLBI · UNIVERSITY OF VIRGINIA · PI Douglas A. Bayliss · 2011 to 2026
$6.5MDeveloping a drug-inducible gene therapy for temporal lobe epilepsyR01NS097726 · NINDS · UNIVERSITY OF VIRGINIA · PI PEREZ-REYES, EDWARD · 2016 to 2019
$1.4MDissecting a novel prefrontal cortical pathway regulating feeding behaviorK08DK118201 · NIDDK · MCLEAN HOSPITAL · PI ROSS, RACHEL A · 2019 to 2022
$963kNHLBI NIH HHS R01 HL074011NHLBI NIH HHS R01 HL108609NHLBI NIH HHS T32 HL007374NIDDK NIH HHS K08 DK118201NIDDK NIH HHS R01 DK075632NIDDK NIH HHS R01 DK096010NINDS NIH HHS R01 NS097726
Abstract
Among numerous challenges encountered at the beginning of extrauterine life, the most celebrated is the first breath that initiates a life-sustaining motor activity
Indexed as
RespirationAnimalsApneaBrain StemCarbon DioxideFemaleMaleMiceNeuronsParturitionPituitary Adenylate Cyclase-Activating PolypeptideReceptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type IAdcyap1r1 protein, mouseCarbon DioxidePituitary Adenylate Cyclase-Activating PolypeptideReceptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.