ArticleNature2020
Galactosaminogalactan activates the inflammasome to provide host protection.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 81 papers.
0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
6.3field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed, 126 citations in OpenAlex.
- Selectively targeting UDP-glucose 4-epimerase MoUGE1 for controlling rice blast disease.Journal of advanced research · 2026Article
- DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy.MedComm · 2026Review
- Breakthrough mucormycosis after hematopoietic stem cell transplantation: a retrospective multiyear cohort study in Eastern China.Annals of clinical microbiology and antimicrobials · 2026Observational
- Aspergillosis: An Update on Epidemiology, Risk Factors, Diagnosis, Susceptibility, and Treatment.Journal of fungi (Basel, Switzerland) · 2026Review
- CsdA-LaeB Regulatory Hub Contributes to Aspergillus fumigatus Virulence via Fumiquinazoline C Biosynthesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Oxidoreductase geneMicrobiology spectrum · 2026Article
- The structural language of fungal cell wall sugars in WHO priority fungi: the determinant of pathogenicity and the gateway to new therapies.Frontiers in immunology · 2026Review
- When glycobiology meets inflammasome activation: Insights and implications.Journal of advanced research · 2026Review
- Deciphering the role of the Sch9 serine/threonine kinase inFrontiers in fungal biology · 2026Article
- Cytosolic receptors and signaling in antifungal immunity.The EMBO journal · 2025Review
- Molecular mechanisms and regulation of inflammasome activation and signaling: sensing of pathogens and damage molecular patterns.Cellular & molecular immunology · 2025Review
- Computational Approaches for Discovering Virulence Factors inJournal of fungi (Basel, Switzerland) · 2025Review
- Homeostasis of Gut Microbiota Protects against Susceptibility to Fungal Pneumonia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Aspergillus fumigatus biology, immunopathogenicity and drug resistance.Nature reviews. Microbiology · 2025Review
- Regulation of Necroptosis by Aspergillus fumigatus Exopolysaccharide in Human Macrophages Derived from THP-1 Cells: Involvement of the RIP1-RIP3-MLKL Signaling Axis.Current microbiology · 2025Article
- Condition-dependent effects of Elexacaftor/Tezacaftor/Ivacaftor (Trikafta) onMicrobiology spectrum · 2025Article
- Exopolysaccharides of Ganoderma lucidum Activate the NLRP3 Inflammasome, Modulating Phagocytes and the Response of Mice to Infection with Cryptococcus neoformans.Mycopathologia · 2025Article
- Updated insights into the molecular networks for NLRP3 inflammasome activation.Cellular & molecular immunology · 2025Review
- Recent developments inMicrobiology and molecular biology reviews : MMBR · 2025Review
- Discovery of a novel translation-machinery-associated protein that positively correlates with cellulase production.Biotechnology for biofuels and bioproducts · 2025Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
18 authors at 4 institutions in 5 countries.
Benoit BriardDepartment of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-1496-9408
Thierry FontaineUnité des Aspergillus, Institut Pasteur, Paris, France.
Parimal SamirDepartment of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0001-7655-5713
David E PlaceDepartment of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-1904-4164
Laetitia MuszkietaUnité des Aspergillus, Institut Pasteur, Paris, France.
R K Subbarao MalireddiDepartment of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0001-8855-9447
Rajendra KarkiDepartment of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0003-4436-9128
Shelbi ChristgenDepartment of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0003-1145-4430
Perrine BommeUltrastructural Bio Imaging Unit, C2RT, Institut Pasteur, Paris, France.
Peter VogelAnimal Resources Center and the Veterinary Pathology Core, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-7535-0545
Rémi BeauUnité des Aspergillus, Institut Pasteur, Paris, France.
Emilia MelladoMycology Reference Laboratory, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Madrid, Spain.
Oumaima Ibrahim-GranetUnité des Cytokines et Inflammation, Institut Pasteur, Paris, France.
Bernard HenrissatAFMB, UMR 7257 CNRS, Aix-Marseille Université, Marseille, France.ORCID http://orcid.org/0000-0002-3434-8588
Ravi C KalathurDepartment of Structural Biology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-4889-8003
Cam RobinsonCell and Tissue Imaging Center, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-7277-692X
Jean-Paul LatgéUnité des Aspergillus, Institut Pasteur, Paris, France.
Thirumala-Devi KannegantiDepartment of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA. Thirumala-Devi.Kanneganti@StJude.org.ORCID http://orcid.org/0000-0002-6395-6443
St. Jude Children's Research Hospital · USInstitut Pasteur · FRCentre National de la Recherche Scientifique · FRInstituto de Salud Carlos III · ES
Funding
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MInnate immune sensors, inflammasomes, and inflammasome-mediated processes in cancerR35CA253095 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Thirumala-Devi Kanneganti · 2020 to 2026
$7.0MRole of NLR Inflammasomes in Autoinflammatory Diseases and Host DefenseR01AR056296 · NIAMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI KANNEGANTI, THIRUMALA-DEVI · 2008 to 2022
$5.9MThe Non-Inflammasome NLRs in Immunity and Host defenseR01AI124346 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Thirumala-Devi Kanneganti · 2016 to 2026
$5.8MInflammatory Caspases in Innate Immunity and InflammationR37AI101935 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Thirumala-Devi Kanneganti · 2017 to 2026
$4.9MNLR signaling in colitis and colorectal tumorigenesisR01CA163507 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI KANNEGANTI, THIRUMALA-DEVI · 2012 to 2020
$3.5MInflammatory Caspases in Innate Immunity and InflammationR01AI101935 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI KANNEGANTI, THIRUMALA-DEVI · 2012 to 2016
$2.2MNCI NIH HHS P30 CA021765NCI NIH HHS R01 CA163507NCI NIH HHS R35 CA253095NIAID NIH HHS R01 AI101935NIAID NIH HHS R01 AI124346NIAID NIH HHS R37 AI101935NIAMS NIH HHS R01 AR056296NIH HHS AI 056296NIH HHS AI 101935NIH HHS AI124346NIH HHS CA 253095
Abstract
Inflammasomes are important sentinels of innate immune defence that are activated in response to diverse stimuli, including pathogen-associated molecular patterns (PAMPs)
Indexed as
AnimalsAspergillosisAspergillus fumigatusBiofilmsColitisDextran SulfateFemaleFungal ProteinsGene DeletionImmunity, InnateInflammasomesMaleMiceNLR Family, Pyrin Domain-Containing 3 ProteinPathogen-Associated Molecular Pattern MoleculesPolysaccharidesDextran SulfateFungal ProteinsgalactosaminogalactanInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mousePathogen-Associated Molecular Pattern MoleculesPolysaccharidesRibosomal Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.