Evidence map›Paper›PMID 33268893›Full record

ArticleNature2020

Cryo-EM structure of the inhibited (10S) form of myosin II.

Shixin Yang, Prince Tiwari, Kyoung Hwan Lee, Osamu Sato, Mitsuo Ikebe, Raúl Padrón, Roger Craig

Abstract read
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Smooth muscle contractile cytoskeleton in health and disease.Journal of muscle research and cell motility · 2026
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Structural basis of nonmuscle myosin-2 autoinhibition mechanisms.bioRxiv : the preprint server for biology · 2025
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Non-Muscle Myosin II A: Friend or Foe in Cancer?International journal of molecular sciences · 2024
    Review
  18. Article
  19. Structure, regulation, and mechanisms of nonmuscle myosin-2.Cellular and molecular life sciences : CMLS · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shixin Yang *Division of Cell Biology and Imaging, Department of Radiology, University of Massachusetts Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0002-9794-7537
Prince Tiwari *Division of Cell Biology and Imaging, Department of Radiology, University of Massachusetts Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0003-4062-1648
Kyoung Hwan LeeDivision of Cell Biology and Imaging, Department of Radiology, University of Massachusetts Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0003-1423-8952
Osamu SatoDepartment of Cellular and Molecular Biology, University of Texas Health Science Center at Tyler, Tyler, TX, USA.ORCID http://orcid.org/0000-0001-9913-1745
Mitsuo IkebeDepartment of Cellular and Molecular Biology, University of Texas Health Science Center at Tyler, Tyler, TX, USA.ORCID http://orcid.org/0000-0002-8299-6643
Raúl PadrónDivision of Cell Biology and Imaging, Department of Radiology, University of Massachusetts Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0002-1412-2450
Roger CraigDivision of Cell Biology and Imaging, Department of Radiology, University of Massachusetts Medical School, Worcester, MA, USA. roger.craig@umassmed.edu.ORCID http://orcid.org/0000-0002-9707-5409

Funding

Mechanism of regulation of cardiac contraction by phosphorylation of myosin binding protein CR01HL139883 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI CRAIG, ROGER W, RALPHE, JOHN CARTER · 2018 to 2021
$2.7M
Skeletal Myosin-Binding Protein C (MyBP-C): Molecular Structure and FunctionR01AR067279 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CRAIG, ROGER W, WARSHAW, DAVID M · 2015 to 2019
$2.3M
Structure of The Interacting-Heads Motif in Myosin Filaments and MoleculesR01AR072036 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CRAIG, ROGER W · 2017 to 2021
$2.1M
Myocardin in the pathogenesis of pleural remodelingR01HL142853 · NHLBI · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI IDELL, STEVEN, IKEBE, MITSUO · 2019 to 2022
$1.9M
Murine 3D Engineered Tissue Model of Human MYBPC3 MutationsR01HL107367 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI RALPHE, JOHN CARTER · 2011 to 2015
$1.8M
Rac1 in Smooth MuscleR01HL111696 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI IKEBE, MITSUO · 2012 to 2016
$1.7M
NHLBI NIH HHS R01 HL107367NHLBI NIH HHS R01 HL111696NHLBI NIH HHS R01 HL139883NHLBI NIH HHS R01 HL142853NIAMS NIH HHS R01 AR067279NIAMS NIH HHS R01 AR072036NIH HHS GM103311NIH HHS HL075030NIH HHS HL142853
6 · The paper itself

Abstract

Myosin II is the motor protein that enables muscle cells to contract and nonmuscle cells to move and change shape

Indexed as

Cryoelectron MicroscopyAnimalsBinding SitesModels, MolecularMuscle, SmoothMutationMyosin Type IIPhosphorylationProtein BindingProtein ConformationProtein UnfoldingTurkeysMyosin Type II

Identifiers

PMID33268893
PMCPMC7746622

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.