ArticleNature2021
Structure of the class D GPCR Ste2 dimer coupled to two G proteins.
Open access · greenAbstract readComparative Study
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
57 citing papers in PubMed, 91 citations in OpenAlex.
- Atomic, structural and molecular insights into GPCR ligand binding and signalling.Nature reviews. Molecular cell biology · 2026Review
- Protein Frustration Reveals Orthosteric and Allosteric Active Sites in GPCR:G Protein Complexes.Journal of chemical information and modeling · 2026Article
- Prevalence, distribution, and mechanisms of genetic dominance in the yeast mating pathway.Genetics · 2026Article
- Structural characterization of kappa-opioid receptor dimer in complex with two G proteins.Nature communications · 2026Article
- Molecular basis of antagonism of the dimeric human arginine vasopressin receptor 1A.Nature communications · 2026Article
- Sequence constraints predispose Class D GPCRs to follow an atypical activation mechanism.bioRxiv : the preprint server for biology · 2026Article
- GPCR Heterodimers: Implications for Biased Signaling.Handbook of experimental pharmacology · 2026Review
- Prevalence, distribution, and mechanisms of genetic dominance in the yeast mating pathway.bioRxiv : the preprint server for biology · 2025Article
- Deep learning reveals endogenous sterols as allosteric modulators of the GPCR-Gα interface.eLife · 2025Article
- Elucidating biased signaling in class A GPCRs.Trends in pharmacological sciences · 2025Review
- G protein-coupled receptors: pivotal hubs in gastric cancer malignancy-from multidimensional crosstalk to precision therapeutics.Journal of translational medicine · 2025Review
- Mechanistic insights from the atomic-level quaternary structure of short-lived GPCR oligomers of the human secretin receptor in live cells.Communications biology · 2025Article
- A large-scale curated and filterable dataset for cryo-EM foundation model pre-training.Scientific data · 2025Article
- The rise of fungal G-protein coupled receptors in pathogenesis and symbiosis.PLoS pathogens · 2025Article
- Decoding fungal communication networks: molecular signaling, genetic regulation, and ecological implications.Functional & integrative genomics · 2025Review
- Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2.Molecular cell · 2025Article
- Structural insights into the regulation of monomeric and dimeric apelin receptor.Nature communications · 2025Article
- The dual-site agonist for human M2 muscarinic receptors Iper-8-naphtalimide induces mitochondrial dysfunction inMicrobial cell (Graz, Austria) · 2025Article
- VPS26 Moonlights as a β-Arrestin-like Adapter for a 7-Transmembrane RGS Protein inBiochemistry · 2024Article
- Conserved signaling modules regulate filamentous growth in fungi: a model for eukaryotic cell differentiation.Genetics · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 4 countries.
Vaithish VelazhahanMRC Laboratory of Molecular Biology, Cambridge, UK.
Ning MaDepartment of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA, USA.
Gáspár Pándy-SzekeresDepartment of Drug Design and Pharmacology, Universitetsparken 2, Copenhagen, Denmark.
Albert J KooistraDepartment of Drug Design and Pharmacology, Universitetsparken 2, Copenhagen, Denmark.
Yang LeeMRC Laboratory of Molecular Biology, Cambridge, UK.ORCID http://orcid.org/0000-0002-8040-3648
David E GloriamDepartment of Drug Design and Pharmacology, Universitetsparken 2, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-4299-7561
Nagarajan VaidehiDepartment of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA, USA.ORCID http://orcid.org/0000-0001-8100-8132
Christopher G TateMRC Laboratory of Molecular Biology, Cambridge, UK. cgt@mrc-lmb.cam.ac.uk.ORCID http://orcid.org/0000-0002-2008-9183
MRC Laboratory of Molecular Biology · GBUniversity of Copenhagen · DKCity of Hope · US
Funding
Structural dynamics underlying GPCR-G protein selectivityR01GM117923 · NIGMS · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI VAIDEHI, NAGARAJAN · 2017 to 2024
$3.8MComputationally Guided Design of Thermostable mutants of Neurotensin receptor1R01GM097261 · NIGMS · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI VAIDEHI, NAGARAJAN · 2011 to 2018
$2.3MAn integrated toolkit combining computational systems biology techniques with molecular dynamics simulations to delineate functionality of GPCRsR01LM013876 · NLM · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI RODIN, ANDREI, VAIDEHI, NAGARAJAN · 2022 to 2025
$1.5MMedical Research Council MC_U105197215MRF_ MRF-110-057-S-RADA-C0940NIGMS NIH HHS R01 GM097261NIGMS NIH HHS R01 GM117923NLM NIH HHS R01 LM013876
Abstract
G-protein-coupled receptors (GPCRs) are divided phylogenetically into six classes
Indexed as
Cryoelectron MicroscopyProtein MultimerizationAmino Acid SequenceBinding SitesGTP-Binding Protein alpha Subunits, Gq-G11GTP-Binding Protein beta SubunitsGTP-Binding Protein gamma SubunitsHeterotrimeric GTP-Binding ProteinsHumansModels, MolecularProtein PrecursorsReceptors, Mating FactorSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSequence AlignmentGPA1 protein, S cerevisiaeGTP-Binding Protein alpha Subunits, Gq-G11GTP-Binding Protein beta SubunitsGTP-Binding Protein gamma SubunitsHeterotrimeric GTP-Binding ProteinsMF(ALPHA)1 protein, S cerevisiaeProtein PrecursorsReceptors, Mating FactorSaccharomyces cerevisiae ProteinsSTE18 protein, S cerevisiaeSTE2 protein, S cerevisiaeSte4 protein, S cerevisiae
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.