Evidence map›Paper›PMID 33268535›Full record

ArticleJournal of clinical microbiology2021

Comparative Analytical Evaluation of Four Centralized Platforms for the Detection of Mycobacterium tuberculosis Complex and Resistance to Rifampicin and Isoniazid.

Margaretha de Vos, Lesley Scott, Anura David, Andre Trollip, Harald Hoffmann, Sophia Georghiou, Sergio Carmona, Morten Ruhwald, Wendy Stevens, Claudia M Denkinger and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
0.3field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 29 citations in OpenAlex.

  1. Clinical performance of the Abbott RealTime Mycobacterium tuberculosis (MTB) PCR on bronchoscopic specimens for diagnosing pulmonary tuberculosis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  2. Article
  3. Review
  4. Use of reverse dot blot hybridization DNA-array and targeted next-generation sequencing for the detection of drug resistance in patients with tuberculosis: a prospective diagnostic accuracy study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Xpert MTB/RIF Ultra 'trace': considerations for diagnostics.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2025
    Article
  10. Article
  11. Reply to Adzemovic et al.Open forum infectious diseases · 2025
    Article
  12. Article
  13. Article
  14. Review
  15. Drug resistance profiles ofJAC-antimicrobial resistance · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Advances in TB testing.Advances in clinical chemistry · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Margaretha de VosFoundation for Innovative New Diagnostics, Geneva, Switzerland Margaretha.devos@finddx.org.ORCID 0000-0003-3059-2986
Lesley ScottDepartment of Molecular Medicine and Haematology, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Anura DavidDepartment of Molecular Medicine and Haematology, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID 0000-0003-1590-198X
Andre TrollipFoundation for Innovative New Diagnostics, Geneva, Switzerland.
Harald HoffmannInstitute of Microbiology and Laboratory Medicine, Department IML Red GmbH, WHO-Supranational Reference Laboratory of Tuberculosis, Munich-Gauting, Germany.
Sophia GeorghiouFoundation for Innovative New Diagnostics, Geneva, Switzerland.
Sergio CarmonaFoundation for Innovative New Diagnostics, Geneva, Switzerland.
Morten RuhwaldFoundation for Innovative New Diagnostics, Geneva, Switzerland.
Wendy StevensDepartment of Molecular Medicine and Haematology, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Claudia M DenkingerFoundation for Innovative New Diagnostics, Geneva, Switzerland.ORCID 0000-0002-7216-7067
Samuel G SchumacherFoundation for Innovative New Diagnostics, Geneva, Switzerland.ORCID 0000-0002-6136-206X
FIND · CHUniversity of the Witwatersrand · ZANational Health Laboratory Service · ZASynlab (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Failure to rapidly identify drug-resistant tuberculosis (TB) increases the risk of patient mismanagement, the amplification of drug resistance, and ongoing transmission. We generated comparative analytical data for four automated assays for the detection of TB and multidrug-resistant TB (MDR-TB): Abbott RealTi

Indexed as

Mycobacterium tuberculosisTuberculosis, Multidrug-ResistantHumansIsoniazidMicrobial Sensitivity TestsRifampinSensitivity and SpecificityIsoniazidRifampindiagnosisdiagnosticsmultidrug resistancemycobacterium infectionsMycobacterium tuberculosistuberculosis

Identifiers

PMID33268535
PMCPMC8106716
OpenAlexW3110408879

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.