ArticleJournal of neurology, neurosurgery, and psychiatry2021
Late onset depression: dopaminergic deficit and clinical features of prodromal Parkinson's disease: a cross-sectional study.
Article in Journal of neurology, neurosurgery, and psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 61 citations in OpenAlex.
- Sex-specific differences and diagnostic tool performance in the neuropsychiatric profile of Parkinson's disease.BMC neurology · 2026Article
- Trajectories of late-life depression: insights from molecular imaging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Motor signs in late life depression relate to altered subcortical synaptic density and gray matter volume: anNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Late-Onset Depression in an Aging World: A Multidimensional Perspective on Risks, Mechanisms, and Treatment.Geriatrics (Basel, Switzerland) · 2026Review
- Depression in older adults with epilepsy: Pathophysiology and management considerations.Epilepsy & behavior : E&B · 2025Review
- Differentiating Treatment-Resistant Depression With and Without Parkinsonism in the Elderly From a Psychiatric Perspective byInternational journal of geriatric psychiatry · 2025Article
- Improvement of apathy in early Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Prediction of late-onset depression in the elderly Korean population using machine learning algorithms.Scientific reports · 2025Article
- Clinical characteristics and risk factors of depression in prodromal Parkinson's disease.Frontiers in neuroscience · 2025Article
- Depression preceding and following the diagnosis of Parkinson's disease and Lewy body dementia.General psychiatry · 2025Article
- Neuroanatomical substrates of depression in dementia with Lewy bodies and Alzheimer's disease.GeroScience · 2024Article
- Article
- Neuroanatomical and prognostic associations of depression in Parkinson's disease.Journal of neurology, neurosurgery, and psychiatry · 2024Article
- Shared and distinct cortical morphometric alterations in five neuropsychiatric symptoms of Parkinson's disease.Translational psychiatry · 2024Article
- Potential dopaminergic deficit in patients with geriatric psychiatric disorders as revealed by DAT-SPECT: a cross-sectional study.BMJ mental health · 2024Article
- Distinguishing features of depression in dementia from primary psychiatric disease.Discover mental health · 2024Review
- Associations of motor and neuropsychiatric symptoms with comorbidities in prodromal Parkinson's disease.Frontiers in aging neuroscience · 2024Article
- Depression in dementia with Lewy bodies: a critical update.Journal of neural transmission (Vienna, Austria : 1996) · 2023Review
- Local genetic correlations exist among neurodegenerative and neuropsychiatric diseases.NPJ Parkinson's disease · 2023Article
- Synergistic associations of depressive symptoms and aging on cognitive decline in early Parkinson's disease.Clinical parkinsonism & related disorders · 2023Article
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Authors and funding
8 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundLate onset depression (LOD) may precede the diagnosis of Parkinson's disease (PD) or dementia with Lewy bodies (DLB). We aimed to determine the rate of clinical and imaging features associated with prodromal PD/DLB in patients with LOD.
methodsIn a cross-sectional design, 36 patients with first onset of a depressive disorder (Diagnostic and Statistical Manual of Mental Disorders IV criteria) diagnosed after the age of 55 (LOD group) and 30 healthy controls (HC) underwent a detailed clinical assessment. In addition, 28/36 patients with LOD and 20/30 HC underwent a head MRI and 29/36 and 25/30, respectively, had dopamine transporter imaging by
resultsPatients with LOD (n=36) had significantly worse scores than HC (n=30) on the PD screening questionnaire (mean (SD) 1.8 (1.9) vs 0.8 (1.2); p=0.01), Movement Disorder Society Unified Parkinson's Disease Rating Scale total (mean (SD) 19.2 (12.7) vs 6.1 (5.7); p<0.001), REM-sleep behaviour disorder screening questionnaire (mean (SD) 4.3 (3.2) vs 2.1 (2.1); p=0.001), Lille Apathy Rating Scale (mean (SD) -23.3 (9.6) vs -27.0 (4.7); p=0.04) and the Scales for Outcomes in PD-Autonomic (mean (SD) 14.9 (8.7) vs 7.7 (4.9); p<0.001). Twenty-four per cent of patients with LOD versus 4% HC had an abnormal
conclusionsLOD is associated with increased rates of motor and non-motor features of PD/DLB and of abnormal
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