ArticleCancer discovery2021
Genetic Ancestry Contributes to Somatic Mutations in Lung Cancers from Admixed Latin American Populations.
3 registry-linked trialsOpen access · greenAbstract read
In one paragraph
Article in Cancer discovery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 90 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 3 pooled it
6.0field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Phase II Study to Evaluate the Efficacy and Safety of SBRT as an Adjunctive Intervention for Oligoresidual Disease in EGFR Mutant NSCLC With First-Line Osimertinib Treatment
Prevalence of Pathogenic or Likely Pathogenic Germline Variants in Cancer Predisposition Genes Among Patients With Lung Adenocarcinoma
A Prospective Observational Study to Determine the Utility of Lung Cancer Screening for Early Detection of Suspicious Lung Nodules in Latin America
Who cites it
90 citing papers in PubMed, 3 syntheses or guidelines pooled it, 146 citations in OpenAlex.
- Genome-wide meta-analysis across East Asian and European populations provides insights into the molecular basis of lung cancer.Genome medicine · 2026Pooled it
- Meta-analysis reveals differences in somatic alterations by genetic ancestry across common cancers.Nature genetics · 2025Pooled it
- Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population.Nature communications · 2023Pooled it
- Patient-Level KRAS G12C Prevalence among Hispanic/Latino and Non-Hispanic White Patients in Real-world Clinicogenomic Cohorts.Cancer research communications · 2026Article
- Recent advances in engineered nanozymes for precision lung cancer therapy.Materials today. Bio · 2026Review
- A Non-Canonical Core Transcriptional Regulatory Circuit Orchestrates Chromatin Reprogramming to Drive Osimertinib Resistance in Non-Small Cell Lung Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Prevalence and Clinical Implications of Somatic and Germline EGFR Mutations in Patients with Non-Small-Cell Lung Cancer.Cancers · 2026Review
- Insights into inherited genetic variations and genetic ancestry of patients with high-risk melanoma.Melanoma research · 2026Article
- Global Geo-Pharmacogenomics: Environmental Mutational Signatures Drive Population-Level Heterogeneity in Anticancer Drug Response.Journal of xenobiotics · 2026Article
- Clinical and molecular characterization of a large Brazilian lung cancer cohort: a real-world observational study.Lancet regional health. Americas · 2026Article
- Article
- Immune gene diversity and STING1 variants in shaping cancer immunity across different genetic ancestry populations.Cell reports · 2026Article
- Association of germline variants with KRAS-mutation status in colorectal cancer.Scientific reports · 2026Article
- Concurrent Germline-Somatic Alterations and Associations with Cancer Outcomes: A Systematic Review of Concurrent Data Use.Research square · 2026Article
- A world map of air pollution and EGFR-mutant prevalence.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Worse Clinical and Survival Outcomes in Breast Cancer Patients Living in Puerto Rico Compared to Hispanics, Non-Hispanic Blacks, and Non-Hispanic Whites from Florida.Journal of racial and ethnic health disparities · 2026Article
- Study protocol: analysis of gene expression profiles in peripheral blood and tumor tissue of Colombian patients diagnosed with epithelial ovarian cancer.Frontiers in oncology · 2026Article
- Cancer Incidence and Mortality Estimates in Latin America and the Caribbean: A Systematic Analysis of the GLOBOCAN 2022.Cancer research communications · 2025Article
- Prognostic impact ofTranslational lung cancer research · 2025Article
- Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
18 authors at 8 institutions in 6 countries.
Jian Carrot-ZhangDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Giovanny Soca-ChafrePersonalized Medicine Laboratory, Instituto Nacional de Cancerologia, México City, México.ORCID 0000-0003-3985-9149
Nick PattersonBroad Institute of MIT and Harvard, Cambridge, Massachusetts.
Aaron R ThornerDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.ORCID 0000-0002-9160-7881
Anwesha NagDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Jacqueline WatsonDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Giulio GenoveseBroad Institute of MIT and Harvard, Cambridge, Massachusetts.
July RodriguezFoundation for Clinical and Applied Cancer Research - FICMAC, Bogotá, Colombia.
Maya K GelbardDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Luis Corrales-RodriguezMedical Oncology, Hospital San Juan de Dios, San José, Costa Rica.
Yoichiro MitsuishiDivision of Respiratory Medicine, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo, Japan.
Gavin HaDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.ORCID 0000-0001-7578-7272
Joshua D CampbellDivision of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts.ORCID 0000-0003-0780-8662
Geoffrey R OxnardDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Oscar ArrietaPersonalized Medicine Laboratory, Instituto Nacional de Cancerologia, México City, México. matthew_meyerson@dfci.harvard.edu alexander_gusev@dfci.harvard.edu a_cardonaz@yahoo.com scararrietaincan@gmail.com.ORCID 0000-0002-1164-3779
Andres F CardonaFoundation for Clinical and Applied Cancer Research - FICMAC, Bogotá, Colombia. matthew_meyerson@dfci.harvard.edu alexander_gusev@dfci.harvard.edu a_cardonaz@yahoo.com scararrietaincan@gmail.com.
Alexander GusevDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. matthew_meyerson@dfci.harvard.edu alexander_gusev@dfci.harvard.edu a_cardonaz@yahoo.com scararrietaincan@gmail.com.
Matthew MeyersonDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. matthew_meyerson@dfci.harvard.edu alexander_gusev@dfci.harvard.edu a_cardonaz@yahoo.com scararrietaincan@gmail.com.
Broad Institute · USDana-Farber Cancer Institute · USFoundation for Clinical and Applied Cancer Research · COInstituto Nacional de Cancerología · MXBoston University · USFred Hutch Cancer Center · USJuntendo University · JPUniversidad de Costa Rica · CR
Funding
NKX2-1 Enhancer Amplification and Lineage Addiction in Lung AdenocarcinomaR35CA197568 · NCI · DANA-FARBER CANCER INST · PI Matthew L. Meyerson · 2015 to 2026
$12.4MInhibitor-sensitive and -resistant EGFR mutants from lung cancer and glioblastomaR01CA116020 · NCI · DANA-FARBER CANCER INST · PI ECK, MICHAEL J, MEYERSON, MATTHEW L. · 2006 to 2022
$5.1M(PQ3) A functional genomic approach to identification and interpretation of germline-tumor genetic interactionsR01CA227237 · NCI · DANA-FARBER CANCER INST · PI GUSEV, ALEXANDER, ZAITLEN, NOAH A · 2018 to 2022
$3.5MNCI NIH HHS R01 CA116020NCI NIH HHS R01 CA227237NCI NIH HHS R35 CA197568
Abstract
Inherited lung cancer risk, particularly in nonsmokers, is poorly understood. Genomic and ancestry analysis of 1,153 lung cancers from Latin America revealed striking associations between Native American ancestry and their somatic landscape, including tumor mutational burden, and specific driver mutations in
Indexed as
Genetic Predisposition to DiseaseGerm-Line MutationMutationAllelesBiomarkers, TumorGenetic Association StudiesGenomicsHispanic or LatinoHumansLatin AmericaLung NeoplasmsMutation RatePopulation SurveillanceBiomarkers, Tumor
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.