ArticlePediatrics2021
Evaluating Definitions for Neonatal Abstinence Syndrome.
Article in Pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Prenatal opioid exposure, and health, social and educational outcomes for school-aged children: A systematic review.Addiction (Abingdon, England) · 2026Pooled it
- Mixed-Methods Evaluation of Massachusetts' Neonatal Abstinence Syndrome Surveillance System, 2020-2022.AJPM focus · 2026Article
- Neonatal Abstinence Syndrome in the MATernaL and Infant clinical NetworK.Hospital pediatrics · 2025Article
- Longitudinal impact of a perioperative pathway for spinal fusion in adolescent idiopathic scoliosis: a quality improvement project.Spine deformity · 2025Article
- Clinical and demographic predictors of the need for pharmacotherapy in neonatal abstinence syndrome.Frontiers in pediatrics · 2025Article
- Impact of a qualitative assessment approach for neonatal abstinence syndrome management: experience of a European reference center.Italian journal of pediatrics · 2024Article
- Hospital Readmissions Among Infants With Neonatal Opioid Withdrawal Syndrome.JAMA network open · 2024Article
- Hospital Readmissions Among Infants With Neonatal Opioid Withdrawal Syndrome.JAMA network open · 2024Article
- Hospital Readmissions Among Infants With Neonatal Opioid Withdrawal Syndrome.JAMA network open · 2024Article
- Adverse Maternal Experiences and Neonatal Abstinence Syndrome.Maternal and child health journal · 2023Article
- Newborn Cry Acoustics in the Assessment of Neonatal Opioid Withdrawal Syndrome Using Machine Learning.JAMA network open · 2022Article
- Intrauterine drug exposure as a risk factor for cerebral palsy.Developmental medicine and child neurology · 2022Article
- Improving the Assessment of Neonatal Abstinence Syndrome (NAS).Children (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
objectivesNational estimates indicate that the incidence of neonatal abstinence syndrome (NAS), a postnatal opioid withdrawal syndrome, increased more than fivefold between 2004 and 2016. There is no gold standard definition for capturing NAS across clinical, research, and public health settings. Our objective was to evaluate how different definitions of NAS modify the calculated incidence when applied to a known population of opioid-exposed infants.
methodsData for this retrospective cohort study were obtained from opioid-exposed infants born at Vanderbilt University Medical Center in 2018. Six commonly used clinical and surveillance definitions of opioid exposure and NAS were applied to the study population and evaluated for accuracy in assessing clinical withdrawal.
resultsA total of 121 opioid-exposed infants met the criteria for inclusion in our study. The proportion of infants who met criteria for NAS varied by predefined definition, ranging from 17.4% for infants who received morphine to 52.8% for infants with the diagnostic code for opioid exposure. Twenty-eight infants (23.1%) received a clinical diagnosis of NAS by a medical provider, and 38 (34.1%) received the diagnostic code for NAS at discharge.
conclusionsWe found significant variability in the incidence of opioid exposure and NAS among a single-center population using 6 common definitions. Our findings suggest a need to develop a gold standard definition to be used across clinical, research, and public health surveillance settings.
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