ArticleThe Journal of biological chemistry
Lactate fluxes mediated by the monocarboxylate transporter-1 are key determinants of the metabolic activity of beige adipocytes.
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Article in The Journal of biological chemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 32 citations in OpenAlex.
- Mechanisms of obesogenic adipocyte signaling in mouse 3T3-L1 cells in response to plasma from C57BL/6 mice exposed to traffic-generated emissions and high-fat diet.Toxicology reports · 2026Article
- Review
- Rewiring Adipocyte Plasticity: The Redox-Mitochondrial Axis as a Driver of Beige Fat Immunometabolism and Adipose Inflammation.Biomolecules · 2026Review
- MCT1 as a critical regulator of insulin signaling, energy homeostasis and podocyte function.Scientific reports · 2026Article
- Lactate: elucidating its indispensable role in human health.Molecular cancer · 2026Review
- Brown adipose tissue activity impacts systemic lactate clearance in male mice.The Journal of physiology · 2025Article
- Overflow metabolism in bacterial, yeast, and mammalian cells: different names, same game.Molecular systems biology · 2025Review
- Poly-L-Lactic Acid Reduces the Volume of Dermal Adipose Tissue Through its Metabolite Lactate.Aesthetic plastic surgery · 2024Article
- Lactate utilization in Lace1 knockout mice promotes browning of inguinal white adipose tissue.Experimental & molecular medicine · 2024Article
- Review
- Lactate coordinated with exercise promoted the browning of inguinal white adipose tissue.Journal of physiology and biochemistry · 2024Article
- Monocarboxylate transporters facilitate succinate uptake into brown adipocytes.Nature metabolism · 2024Article
- Effects of Salinity Stress on Histological Changes, Glucose Metabolism Index and Transcriptomic Profile in Freshwater Shrimp,Animals : an open access journal from MDPI · 2023Article
- Lactate shuttling drives the browning of white adipose tissue after burn.American journal of physiology. Endocrinology and metabolism · 2023Article
- The anorectic and thermogenic effects of pharmacological lactate in male mice are confounded by treatment osmolarity and co-administered counterions.Nature metabolism · 2023Article
- Brown Adipose Tissue-A Translational Perspective.Endocrine reviews · 2023Review
- Role of histone lactylation interference RNA mFrontiers in cell and developmental biology · 2023Review
- Overexpressing the hydroxycarboxylic acid receptor 1 in mouse brown adipose tissue restores glucose tolerance and insulin sensitivity in diet-induced obese mice.American journal of physiology. Endocrinology and metabolism · 2022Article
- Beta-hydroxybutyrate dampens adipose progenitors' profibrotic activation through canonical Tgfβ signaling and non-canonical ZFP36-dependent mechanisms.Molecular metabolism · 2022Article
- Review
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Authors and funding
17 authors at 4 institutions in 3 countries.
Damien LagardeSTROMALab, Université de Toulouse, CNRS ERL5311, EFS, INP-ENVT, INSERM U1031, Université Paul Sabatier, Toulouse, France; Institut RESTORE, UMR 1301 INSERM, 5070 CNRS, Université Paul Sabatier, Toulouse, France.
Yannick JeansonSTROMALab, Université de Toulouse, CNRS ERL5311, EFS, INP-ENVT, INSERM U1031, Université Paul Sabatier, Toulouse, France; Institut RESTORE, UMR 1301 INSERM, 5070 CNRS, Université Paul Sabatier, Toulouse, France.
Corinne BarreauSTROMALab, Université de Toulouse, CNRS ERL5311, EFS, INP-ENVT, INSERM U1031, Université Paul Sabatier, Toulouse, France; Institut RESTORE, UMR 1301 INSERM, 5070 CNRS, Université Paul Sabatier, Toulouse, France.
Cedric MoroInstitute of Metabolic and Cardiovascular Diseases, INSERM UMR1048, Paul Sabatier University, Toulouse, France.
Lindsay PeyrigaToulouse Biotechnology Institute TBI - INSA de Toulouse INSA/CNRS 5504 - UMR INSA/INRA 7924, Toulouse, France; MetaboHUB-MetaToul, National Infrastructure of Metabolomics and Fluxomics, Toulouse, France.
Edern CahoreauToulouse Biotechnology Institute TBI - INSA de Toulouse INSA/CNRS 5504 - UMR INSA/INRA 7924, Toulouse, France; MetaboHUB-MetaToul, National Infrastructure of Metabolomics and Fluxomics, Toulouse, France.
Christophe GuissardSTROMALab, Université de Toulouse, CNRS ERL5311, EFS, INP-ENVT, INSERM U1031, Université Paul Sabatier, Toulouse, France; Institut RESTORE, UMR 1301 INSERM, 5070 CNRS, Université Paul Sabatier, Toulouse, France.
Emmanuelle ArnaudSTROMALab, Université de Toulouse, CNRS ERL5311, EFS, INP-ENVT, INSERM U1031, Université Paul Sabatier, Toulouse, France; Institut RESTORE, UMR 1301 INSERM, 5070 CNRS, Université Paul Sabatier, Toulouse, France.
Anne GalinierSTROMALab, Université de Toulouse, CNRS ERL5311, EFS, INP-ENVT, INSERM U1031, Université Paul Sabatier, Toulouse, France; Institut RESTORE, UMR 1301 INSERM, 5070 CNRS, Université Paul Sabatier, Toulouse, France; Institut Fédératif de Biologie, CHU Purpan, Toulouse, France.
Anne-Karine Bouzier-SoreUniversité de Bordeaux, CNRS, CRMSB, UMR 5536, Bordeaux, France.
Luc PellerinINSERM U1082, Université de Poitiers, Poitiers Cedex, France.
Edward T ChouchaniDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
Luc PénicaudSTROMALab, Université de Toulouse, CNRS ERL5311, EFS, INP-ENVT, INSERM U1031, Université Paul Sabatier, Toulouse, France; Institut RESTORE, UMR 1301 INSERM, 5070 CNRS, Université Paul Sabatier, Toulouse, France.
Isabelle AderSTROMALab, Université de Toulouse, CNRS ERL5311, EFS, INP-ENVT, INSERM U1031, Université Paul Sabatier, Toulouse, France; Institut RESTORE, UMR 1301 INSERM, 5070 CNRS, Université Paul Sabatier, Toulouse, France.
Jean-Charles PortaisSTROMALab, Université de Toulouse, CNRS ERL5311, EFS, INP-ENVT, INSERM U1031, Université Paul Sabatier, Toulouse, France; Institut RESTORE, UMR 1301 INSERM, 5070 CNRS, Université Paul Sabatier, Toulouse, France; Toulouse Biotechnology Institute TBI - INSA de Toulouse INSA/CNRS 5504 - UMR INSA/INRA 7924, Toulouse, France; MetaboHUB-MetaToul, National Infrastructure of Metabolomics and Fluxomics, Toulouse, France.
Louis CasteillaSTROMALab, Université de Toulouse, CNRS ERL5311, EFS, INP-ENVT, INSERM U1031, Université Paul Sabatier, Toulouse, France; Institut RESTORE, UMR 1301 INSERM, 5070 CNRS, Université Paul Sabatier, Toulouse, France.
Audrey CarrièreSTROMALab, Université de Toulouse, CNRS ERL5311, EFS, INP-ENVT, INSERM U1031, Université Paul Sabatier, Toulouse, France; Institut RESTORE, UMR 1301 INSERM, 5070 CNRS, Université Paul Sabatier, Toulouse, France. Electronic address: audrey.carriere-pazat@inserm.fr.
Centre National de la Recherche Scientifique · FRHarvard University · USInserm · FRUniversité Toulouse III - Paul Sabatier · FR
Funding
Determining mechanisms of the succinate thermogenesis pathways on UCP1-dependent and UCP1-independent thermogenesisR01DK123095 · NIDDK · DANA-FARBER CANCER INST · PI Edward Thomas Chouchani · 2019 to 2026
$4.2MNIDDK NIH HHS R01 DK123095
Abstract
Activation of energy-dissipating brown/beige adipocytes represents an attractive therapeutic strategy against metabolic disorders. While lactate is known to induce beiging through the regulation of Ucp1 gene expression, the role of lactate transporters on beige adipocytes' ongoing metabolic activity remains poorly understood. To explore the function of the lactate-transporting monocarboxylate transporters (MCTs), we used a combination of primary cell culture studies,
Indexed as
Gene Expression RegulationAdipocytes, BeigeAnimalsLactic AcidMaleMesenchymal Stem CellsMiceMice, Inbred C57BLMonocarboxylate Transport Protein 1Monocarboxylic Acid TransportersSignal TransductionSymportersThermogenesisLactic AcidMonocarboxylate Transport Protein 1Monocarboxylic Acid TransportersSymportersbeige adipocytesglycolysislactate fluxesmonocarboxylate transportersuncoupling protein 1
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