ArticleScience advances2020
Transcriptome and regulatory maps of decidua-derived stromal cells inform gene discovery in preterm birth.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Molecular Mechanism and Pathways of Spontaneous Preterm Birth in Different Gestational Tissues: A Systematic Review of Transcriptome Studies.International journal of molecular sciences · 2026Pooled it
- Genome-wide association meta-analysis identifies five loci associated with postpartum hemorrhage.Nature genetics · 2024Pooled it
- Meta-analysis of genome-wide association studies of gestational duration and spontaneous preterm birth identifies new maternal risk loci.PLoS genetics · 2023Pooled it
- Genetic effects on the timing of parturition and links to fetal birth weight.Nature genetics · 2023Pooled it
- A combined genomic arrhythmia propensity score delineates cumulative risk.Cell reports. Medicine · 2025Article
- Regulation of Alternative Splicing by PARP1 in HTR-8/Svneo Cells: Implications for Placental Development and Spontaneous Abortion.Current medical science · 2024Article
- A genome scale transcriptional regulatory model of the human placenta.Science advances · 2024Article
- Recent Advances in Genomic Studies of Gestational Duration and Preterm Birth.Clinics in perinatology · 2024Review
- Integrative analysis of noncoding mutations identifies the druggable genome in preterm birth.Science advances · 2024Article
- Development and validation of a prediction model on spontaneous preterm birth in twin pregnancy: a retrospective cohort study.Reproductive health · 2023Article
- Single-cell multiomics of the human retina reveals hierarchical transcription factor collaboration in mediating cell type-specific effects of genetic variants on gene regulation.Genome biology · 2023Article
- Stromal cells-specific retinoic acid determines parturition timing at single-cell and spatial-temporal resolution.iScience · 2023Article
- Pregnancy-Associated Bleeding and Genetics: Five Sequence Variants in the Myometrium and Progesterone Signaling Pathway are associated with postpartum hemorrhage.medRxiv : the preprint server for health sciences · 2023Article
- Single cell profiling at the maternal-fetal interface reveals a deficiency of PD-L1Scientific reports · 2023Article
- MicroRNAs emerging coordinate with placental mammals alter pathways in endometrial epithelia important for endometrial function.iScience · 2023Article
- Identification of novel cell-free RNAs in maternal plasma as preterm biomarkers in combination with placental RNA profiles.Journal of translational medicine · 2023Article
- Transposable Elements Continuously Remodel the Regulatory Landscape, Transcriptome, and Function of Decidual Stromal Cells.Genome biology and evolution · 2022Article
- The Estrogen Receptor α Cistrome in Human Endometrium and Epithelial Organoids.Endocrinology · 2022Article
- Protein interaction networks define the genetic architecture of preterm birth.Scientific reports · 2022Article
- Spontaneous preterm birth: Involvement of multiple feto-maternal tissues and organ systems, differing mechanisms, and pathways.Frontiers in endocrinology · 2022Review
Corrections and comments
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Authors and funding
29 authors at 8 institutions in 3 countries.
Funding
Abstract
While a genetic component of preterm birth (PTB) has long been recognized and recently mapped by genome-wide association studies (GWASs), the molecular determinants underlying PTB remain elusive. This stems in part from an incomplete availability of functional genomic annotations in human cell types relevant to pregnancy and PTB. We generated transcriptome (RNA-seq), epigenome (ChIP-seq of H3K27ac, H3K4me1, and H3K4me3 histone modifications), open chromatin (ATAC-seq), and chromatin interaction (promoter capture Hi-C) annotations of cultured primary decidua-derived mesenchymal stromal/stem cells and in vitro differentiated decidual stromal cells and developed a computational framework to integrate these functional annotations with results from a GWAS of gestational duration in 56,384 women. Using these resources, we uncovered additional loci associated with gestational duration and target genes of associated loci. Our strategy illustrates how functional annotations in pregnancy-relevant cell types aid in the experimental follow-up of GWAS for PTB and, likely, other pregnancy-related conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.