Evidence map›Paper›PMID 33268335›Full record

ArticleDiabetes care2021

COVID-19 Severity Is Tripled in the Diabetes Community: A Prospective Analysis of the Pandemic's Impact in Type 1 and Type 2 Diabetes.

Justin M Gregory, James C Slaughter, Sara H Duffus, T Jordan Smith, Lauren M LeStourgeon, Sarah S Jaser, Allison B McCoy, James M Luther, Erin R Giovannetti, Schafer Boeder and 2 more

Erratum issued Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Diabetes care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04970719 (The Efficacy of Baricitinib Plus Remdesivir Compared to Dexamethasone Plus Remdesivir in Hospitalised COVID-19 Patients With Diabetes Mellitus), which is not on this map. Cited by 163 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
163citing papers in PubMed, 5 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04970719 phase3withdrawnnot on this map

The Efficacy of Baricitinib Plus Remdesivir Compared to Dexamethasone Plus Remdesivir in Hospitalised COVID-19 Patients With Diabetes Mellitus

TypeinterventionalSponsorBangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic DisordersRan2021 to 2021Enrolled0ConditionsCOVID-19 PneumoniaArmsBaricitinib, Dexamethasone, Remdesivir
3 · Its place in the literature

Who cites it

163 citing papers in PubMed, 5 syntheses or guidelines pooled it, 261 citations in OpenAlex.

  1. Pooled it
  2. American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2022
    Guideline
  3. Pooled it
  4. Impaired glucose regulation, SARS-CoV-2 infections and adverse COVID-19 outcomes.Translational research : the journal of laboratory and clinical medicine · 2022
    Pooled it
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103 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Justin M GregoryIan M. Burr Division of Pediatric Endocrinology and Diabetes, Vanderbilt University School of Medicine, Nashville, TN justin.m.gregory.1@vumc.org.ORCID 0000-0003-2700-0062
James C SlaughterDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN.
Sara H DuffusIan M. Burr Division of Pediatric Endocrinology and Diabetes, Vanderbilt University School of Medicine, Nashville, TN.
T Jordan SmithIan M. Burr Division of Pediatric Endocrinology and Diabetes, Vanderbilt University School of Medicine, Nashville, TN.
Lauren M LeStourgeonDivision of General Internal Medicine and Public Health, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.
Sarah S JaserIan M. Burr Division of Pediatric Endocrinology and Diabetes, Vanderbilt University School of Medicine, Nashville, TN.ORCID 0000-0002-7958-7662
Allison B McCoyDepartment of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN.
James M LutherDivision of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
Erin R GiovannettiDivision of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, CA.
Schafer BoederDivision of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, CA.
Jeremy H PettusDivision of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, CA.
Daniel J MooreIan M. Burr Division of Pediatric Endocrinology and Diabetes, Vanderbilt University School of Medicine, Nashville, TN.ORCID 0000-0002-6889-9345
Vanderbilt University · USUniversity of California San Diego · USVanderbilt University Medical Center · US

Funding

Translational Research in Endocrinology And Diabetes (TREAD)T32DK007061 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Sarah S Jaser, KEVIN D NISWENDER · 1986 to 2026
$8.0M
Determination of Iatrogenic Hyperinsulinemia's Contribution to Insulin Resistance and Endothelial Dysfunction in Recent-Onset Type 1 DiabetesK23DK123392 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GREGORY, JUSTIN · 2020 to 2022
$558k
NIDDK NIH HHS K23 DK123392NIDDK NIH HHS T32 DK007061
6 · The paper itself

Abstract

objectiveTo quantify and contextualize the risk for coronavirus disease 2019 (COVID-19)-related hospitalization and illness severity in type 1 diabetes. RESEARCH DESIGN AND

methodsWe conducted a prospective cohort study to identify case subjects with COVID-19 across a regional health care network of 137 service locations. Using an electronic health record query, chart review, and patient contact, we identified clinical factors influencing illness severity.

resultsWe identified COVID-19 in 6,138, 40, and 273 patients without diabetes and with type 1 and type 2 diabetes, respectively. Compared with not having diabetes, people with type 1 diabetes had adjusted odds ratios of 3.90 (95% CI 1.75-8.69) for hospitalization and 3.35 (95% CI 1.53-7.33) for greater illness severity, which was similar to risk in type 2 diabetes. Among patients with type 1 diabetes, glycosylated hemoglobin (HbA

conclusionsDiabetes status, both type 1 and type 2, independently increases the adverse impacts of COVID-19. Potentially modifiable factors (e.g., HbA

Indexed as

Severity of Illness IndexComorbidityCOVID-19Diabetes Mellitus, Type 1Diabetes Mellitus, Type 2Electronic Health RecordsFemaleHospitalizationHumansHypertensionMaleMiddle AgedOdds RatioProspective Studies

Identifiers

PMID33268335
PMCPMC7818316
OpenAlexW3108213766

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.