Evidence map›Paper›PMID 33268158›Full record

ArticleSchizophrenia research2020

Abnormalities in white matter tracts in the fronto-striatal-thalamic circuit are associated with verbal performance in 22q11.2DS.

Carina Heller, Saskia Steinmann, James J Levitt, Nikos Makris, Kevin M Antshel, Wanda Fremont, Ioana L Coman, Stefan R Schweinberger, Thomas Weiß, Sylvain Bouix and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Neurocognitive and Socio-Emotional Profile of Children with 22q11.2 Deletion Syndrome: Executive Functions, Social Processing Deficits and Clinical Implications.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2026
    Review
  2. Observational
  3. Article
  4. Article
  5. Review
  6. Article
  7. A cross-comparison of cognitive ability across 8 genomic disorders.Current opinion in genetics & development · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Carina HellerPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Psychiatry and Psychotherapy, Jena University Hospital, Germany; Department of Clinical Psychology, Friedrich-Schiller-University Jena, Germany. Electronic address: carina.heller@uni-jena.de.
Saskia SteinmannPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Psychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
James J LevittPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; VA Boston Healthcare System, Brockton Division, Brockton, MA, USA.
Nikos MakrisPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Departments of Psychiatry and Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Kevin M AntshelDepartment of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA; Department of Psychology, Syracuse University, Syracuse, NY, USA.
Wanda FremontDepartment of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA.
Ioana L ComanDepartment of Computer Science, SUNY Oswego, Oswego, NY, USA.
Stefan R SchweinbergerDepartment of General Psychology, Friedrich-Schiller-University Jena, Germany.
Thomas WeißDepartment of Clinical Psychology, Friedrich-Schiller-University Jena, Germany.
Sylvain BouixPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Marek R KubickiPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Wendy R KatesDepartment of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA.
Zora KikinisPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Brigham and Women's Hospital · USSUNY Upstate Medical University · USFriedrich Schiller University Jena · DEState University of New York at Oswego · US

Funding

Biomarkers for Psychosis in Velocardiofacial SyndromeR01MH064824 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI KATES, WENDY · 2002 to 2015
$7.3M
Neural substrates of diffusion imaging in cognitively aging rhesus monkeysR01AG042512 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI KUBICKI, MAREK, MAKRIS, NIKOLAOS · 2013 to 2023
$6.5M
Mechanisms of myelin damage and cognitive impairment in the aging monkey: Gene Expression, Neurophysiology, Inflammation and Effects of Calorie RestrictionRF1AG043640 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENE, DOUGLAS L · 2019 to 2019
$3.7M
Histopathology, Neuroimaging and Mechanism of Myelin Damage in Aging Monkey BrainR01AG043640 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENE, DOUGLAS L · 2013 to 2017
$3.0M
Diffusion Imaging Biomarkers for Risk, Onset and Outcome in SchizophreniaR01MH102377 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI KUBICKI, MAREK · 2014 to 2018
$2.8M
Mentoring and Neuroimaging Research on White Matter Pathology in SchizophreniaK24MH110807 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI KUBICKI, MAREK · 2017 to 2021
$945k
Mentoring and neuroimaging research on new targets for DBS in OCDK24MH116366 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI MAKRIS, NIKOLAOS · 2018 to 2022
$817k
Structural Connectivity Biomarkers in Prodromes and 22q11.2 Deletion Syndrome.R21MH106793 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI KIKINIS, ZORA · 2016 to 2017
$481k
The Brain Wiring of Frontostriatal Connections in Early PsychosisR21MH121704 · NIMH · HARVARD MEDICAL SCHOOL · PI LEVITT, JAMES JONATHAN · 2020 to 2021
$429k
NIA NIH HHS R01 AG042512NIA NIH HHS R01 AG043640NIA NIH HHS RF1 AG043640NIMH NIH HHS K24 MH110807NIMH NIH HHS K24 MH116366NIMH NIH HHS R01 MH064824NIMH NIH HHS R01 MH102377NIMH NIH HHS R21 MH106793NIMH NIH HHS R21 MH121704
6 · The paper itself

Abstract

backgroundAbnormalities in fronto-striatal-thalamic (FST) sub-circuits are present in schizophrenia and are associated with cognitive impairments. However, it remains unknown whether abnormalities in FST sub-circuits are present before psychosis onset. This may be elucidated by investigating 22q11.2 deletion syndrome (22q11DS), a genetic syndrome associated with a 30% risk for developing schizophrenia in adulthood and a decline in Verbal IQ (VIQ) preceding psychosis onset. Here, we examined white matter (WM) tracts in FST sub-circuits, especially those in the dorsolateral (DLPFC) and ventrolateral prefrontal cortex (VLPFC) sub-circuits, and their associations with VIQ in young adults with 22q11DS.

methodsDiffusion MRI scans were acquired from 21 individuals with 22q11DS with prodromal symptoms of schizophrenia, 30 individuals with 22q11DS without prodromal symptoms, and 30 healthy controls (mean age: 21 ± 2 years). WM tracts were reconstructed between striatum and thalamus with rostral middle frontal gyrus (rMFG) and inferior frontal gyrus (IFG), representing DLPFC and VLPFC respectively. Fractional anisotropy (FA) and radial diffusivity (RD) were used for group comparisons. VIQ was assessed and associations with the diffusion measures were evaluated.

resultsFA was significantly increased and RD decreased in most tracts of the DLPFC and VLPFC sub-circuits in 22q11DS. Verbal IQ scores correlated negatively with FA and, at trend level, positively with RD in the right thalamus-IFG tract in 22q11DS with prodromal symptoms.

conclusionsWhile abnormalities in FST sub-circuits are associated with schizophrenia, we observed that these abnormalities are also present in 22q11DS individuals with prodromal symptoms and are associated with verbal performance in the right thalamus-IFG tract.

Indexed as

DiGeorge SyndromeWhite MatterAdultAnisotropyDiffusion Tensor ImagingHumansThalamusYoung Adult22q11.2 deletion syndromeDiffusion MRIProdromal symptomsSchizophreniaVerbal IQWhite matter

Identifiers

PMID33268158
PMCPMC7727455
OpenAlexW3093666789

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.