ArticleEuropean psychiatry : the journal of the Association of European Psychiatrists2020
Identification of common neural substrates with connectomic abnormalities in four major psychiatric disorders: A connectome-wide association study.
Article in European psychiatry : the journal of the Association of European Psychiatrists, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neurotransmission-related gene expression in the frontal pole is altered in subjects with bipolar disorder and schizophrenia.Translational psychiatry · 2023Pooled it
- Distinct and common subcortical functional connectivity revealed across three major psychiatric disorders.Psychological medicine · 2026Article
- Relearning the epistemology, history, and future of neuropsychiatry.Frontiers in human neuroscience · 2026Review
- Transdiagnostic prevention in youth mental health, Part I: rationale, shared risk factors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Exploring dopamine as the master regulator of brain circuitry and mental health genome.Gene & protein in disease · 2025Article
- Cerebellar and subcortical interplay in cognitive dysmetria: functional network signatures associate with symptom and trait assessments across schizophrenia, bipolar II, and ADHD patients.Brain imaging and behavior · 2025Article
- Common and disease-specific patterns of functional connectivity and topology alterations across unipolar and bipolar disorder during depressive episodes: a transdiagnostic study.Translational psychiatry · 2025Article
- Using big data of genetics, health claims, and brain imaging to challenge the categorical classification in mental illness.Journal of the Chinese Medical Association : JCMA · 2022Review
- Clustering of Multiple Psychiatric Disorders Using Functional Connectivity in the Data-Driven Brain Subnetwork.Frontiers in psychiatry · 2021Article
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9 authors.
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Abstract
backgroundRecent imaging studies of large datasets suggested that psychiatric disorders have common biological substrates. This study aimed to identify all the common neural substrates with connectomic abnormalities across four major psychiatric disorders by using the data-driven connectome-wide association method of multivariate distance matrix regression (MDMR).
methodsThis study analyzed a resting functional magnetic resonance imaging dataset of 100 patients with schizophrenia, 100 patients with bipolar I disorder, 100 patients with bipolar II disorder, 100 patients with major depressive disorder, and 100 healthy controls (HCs). We calculated a voxel-wise 4,330 × 4,330 matrix of whole-brain functional connectivity (FC) with 8-mm isotropic resolution for each participant and then performed MDMR to identify structures where the overall multivariate pattern of FC was significantly different between each patient group and the HC group. A conjunction analysis was performed to identify common neural regions with FC abnormalities across these four psychiatric disorders.
resultsThe conjunction of the MDMR maps revealed that the four groups of patients shared connectomic abnormalities in distributed cortical and subcortical structures, which included bilateral thalamus, cerebellum, frontal pole, supramarginal gyrus, postcentral gyrus, lingual gyrus, lateral occipital cortex, and parahippocampus. The follow-up analysis based on pair-wise FC of these regions demonstrated that these psychiatric disorders also shared similar patterns of FC abnormalities characterized by sensory/subcortical hyperconnectivity, association/subcortical hypoconnectivity, and sensory/association hyperconnectivity.
conclusionsThese findings suggest that major psychiatric disorders share common connectomic abnormalities in distributed cortical and subcortical regions and provide crucial support for the common network hypothesis of major psychiatric disorders.
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