Observational studyBMC pulmonary medicine2020
Clinical profiles of subclinical disease among pulmonary tuberculosis patients: a prospective cohort study in South Korea.
Observational study in BMC pulmonary medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Subclinical tuberculosis: a meta-analysis of prevalence and scoping review of definitions, prevalence and clinical characteristics.European respiratory review : an official journal of the European Respiratory Society · 2024Pooled it
- Screening performance of C-reactive protein for active pulmonary tuberculosis in HIV-positive patients: A systematic review with a meta-analysis.Frontiers in immunology · 2022Pooled it
- Immune endotypes in tuberculosis: Keys to decoding disease complexity.Journal of internal medicine · 2026Review
- Asymptomatic tuberculosis in Japan: a 15-year national surveillance study, 2008-2022.The Lancet regional health. Western Pacific · 2026Article
- "Subclinical tuberculosis": a person-centred critique.ERJ open research · 2026Article
- Asymptomatic tuberculosis detected in health screening predicts favourable outcome.ERJ open research · 2026Article
- High prevalence of persistent tuberculosis-related symptoms 6 months after treatment in pulmonary tuberculosis.BMJ open respiratory research · 2026Observational
- Case Report: Management challenges of active tuberculosis complicated by thrombocytosis and squamous cell lung carcinoma.Frontiers in oncology · 2026Article
- Symptomatic (STB) and Asymptomatic (ATB) tuberculosis in Italy: Results from a multicenter retrospective study.Journal of clinical tuberculosis and other mycobacterial diseases · 2025Article
- Evidence required to evaluate the use of bacteriologically confirmed asymptomatic tuberculosis disease as a primary endpoint in prevention of tuberculosis disease vaccine licensure trials.The Lancet. Respiratory medicine · 2025Review
- Detection of AerosolizedOpen forum infectious diseases · 2025Article
- Characteristics of subclinical pulmonary tuberculosis compared to active pulmonary tuberculosis: A retrospective cohort study.Journal of clinical tuberculosis and other mycobacterial diseases · 2025Article
- The relationship between a known diagnosis of tuberculosis and symptom reporting: implications for case detection strategies.The European respiratory journal · 2025Article
- Prevalence, Progression, and Treatment of Asymptomatic Tuberculosis: A Prospective Cohort Study in Lanxi County, Zhejiang Province, China.Open forum infectious diseases · 2025Article
- Comparative immunophenotyping of peripheral blood lymphocyte subsets in pulmonary tuberculosis and nontuberculous mycobacterial pulmonary disease: a retrospective study.Frontiers in immunology · 2025Article
- Development and Validation of Deep Learning-Based Infectivity Prediction in Pulmonary Tuberculosis Through Chest Radiography: Retrospective Study.Journal of medical Internet research · 2024Article
- Community-Wide Active Case Finding for Tuberculosis: Time to Use the Evidence We Have.Tropical medicine and infectious disease · 2024Review
- Characteristics of culture-negative subclinical pulmonary tuberculosis: a single-center observation.Multidisciplinary respiratory medicine · 2024Article
- Do patients attempt and succeed in quitting smoking during tuberculosis treatment? A prospective cohort study.BMC pulmonary medicine · 2023Article
- Prevalence of subclinical pulmonary tuberculosis and its association with HIV in household contacts of index tuberculosis patients in two South African provinces: a secondary, cross-sectional analysis of a cluster-randomised trial.BMC global and public health · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundSubclinical tuberculosis (TB) is a potential target for public health intervention because its early identification may reduce TB transmission. We aimed to describe the clinical and laboratory findings of subclinical disease among pulmonary TB patients and compared treatment outcomes for subclinical and active diseases.
methodsIn this prospective cohort study, we enrolled adult patients aged ≥ 19 years with pulmonary TB between 2016 and 2018. Subclinical TB was defined as radiographic or microbiologic test results consistent with TB without clinical symptoms. We implemented a two-stage symptom assessment using a predefined TB symptom checklist. Demographic, clinical, and laboratory data were compared between subclinical and active diseases using multivariable binary logistic regression analysis. We evaluated treatment outcomes in the drug-susceptible cohort.
resultsAmong 420 enrolled patients, 81 (19.3%) had subclinical TB. Multivariable analysis showed that age < 65 years was the only variable significantly associated with subclinical disease. Subclinical disease had a significantly lower proportion of acid-fast bacilli smear and culture positivity and multiple lobe involvement compared to active disease. The white blood cell counts, platelet counts, and C-reactive protein levels were significantly higher among patients with active disease than among those with subclinical disease. Among 319 patients with treatment success in the drug-susceptible cohort, six (1.9%) recurrent cases were identified, and all were active disease. Patients with subclinical disease had a higher proportion of favourable outcomes; however, its odds ratio was insignificant.
conclusionsNearly one-fifth of tuberculosis cases were subclinical in South Korea. Despite its milder clinical presentation and lower level of inflammatory markers, the treatment outcomes of subclinical TB were not significantly different from that of active disease.
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