Evidence map›Paper›PMID 33267815›Full record

Trial reportBMC nephrology2020

Separate and combined effects of cold dialysis and intradialytic exercise on the thermoregulatory responses of hemodialysis patients: a randomized-cross-over study.

Argyro A Krase, Andreas D Flouris, Christina Karatzaferi, Christoforos D Giannaki, Ioannis Stefanidis, Giorgos K Sakkas

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03905551 (The Effect of Exercise Rehabilitation Regimes in Combination With Changes in Dialysis Procedures in Aspects Related to Quality of Life and Health in End Stage Renal Disease Patients), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03905551 nacompletednot on this map

The Effect of Exercise Rehabilitation Regimes in Combination With Changes in Dialysis Procedures in Aspects Related to Quality of Life and Health in End Stage Renal Disease Patients

TypeinterventionalSponsorUniversity of ThessalyRan2015 to 2020Enrolled72ConditionsEnd Stage Renal Failure on DialysisArmsCold Dialysis, Typical Dialysis, Exercise
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Exercise training for adults undergoing maintenance dialysis.The Cochrane database of systematic reviews · 2022
    Pooled it
  2. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Argyro A KraseFAME Lab, School of Physical Education, Sport Science and Dietetics, University of Thessaly, Trikala, Greece.
Andreas D FlourisFAME Lab, School of Physical Education, Sport Science and Dietetics, University of Thessaly, Trikala, Greece.
Christina KaratzaferiSchool of Physical Education, Sport Science and Dietetics, University of Thessaly, Trikala, 42100, Greece.
Christoforos D GiannakiDepartment of Life and Health Sciences, University of Nicosia, Nicosia, Cyprus.
Ioannis StefanidisSchool of Health Sciences, Department of Medicine, Division of Nephrology, University of Thessaly, Larissa, Greece.
Giorgos K SakkasSchool of Physical Education, Sport Science and Dietetics, University of Thessaly, Trikala, 42100, Greece. gsakkas@uth.gr.ORCID 0000-0002-2462-995X
University of Thessaly · GRUniversity of Nicosia · CY

Funding

H2020 Marie Skłodowska-Curie Actions 645648H2020 Marie Skłodowska-Curie Actions 645710
6 · The paper itself

Abstract

backgroundThe separate and combined effects of intradialytic exercise training (IET) and cold dialysis (CD) on patient thermoregulation remain unknown. This study assessed the thermoregulatory responses of hemodialysis patients under four different hemodialysis protocols: a) one typical dialysis (TD) protocol (dialysate temperature at 37 °C), b) one cold dialysis (CD) protocol (dialysate temperature at 35 °C), c) one typical dialysis protocol which included a single exercise bout (TD + E), d) one cold dialysis protocol which included a single exercise bout (CD + E).

methodsTen hemodialysis patients (57.2 ± 14.9 years) participated in this randomized, cross-over study. Core and skin temperatures were measured using an ingestible telemetric pill and by four wireless iButtons attached on the skin, respectively. Body heat storage (S) calculated using the thermometric method proposed by Burton.

resultsThe TD and TD + E protocols were associated with increased S leading to moderate effect size increases in core body temperature (as high as 0.4 °C). The low temperature of the dialysate during the CD and the CD + E protocols prevented the rise in S and core temperature (p > 0.05), even during the period that IET took place.

conclusionsTD and IET are accompanied by a moderate level of hyperthermia, which can be offset by CD. We recommended that CD or with IET can prevent the excessive rise of S.

trial registrationClinical Trial Registry number: NCT03905551 ( clinicaltrials.gov ), DOR: 05/04/2019.

Indexed as

Body TemperatureBody Temperature RegulationCold TemperatureExerciseAdultAgedAged, 80 and overCross-Over StudiesDialysis SolutionsFemaleHumansKidney Failure, ChronicMaleMiddle AgedRenal DialysisSkin TemperatureDialysis SolutionsBody temperature during dialysisCold dialysisDialysis temperatureThermal balance

Identifiers

PMID33267815
PMCPMC7709248
OpenAlexW3107286023

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.