Evidence map›Paper›PMID 33267804›Full record

ArticleBMC complementary medicine and therapies2020

Abelmoschus esculentus subfractions attenuate Aβ and tau by regulating DPP-4 and insulin resistance signals.

Chien-Ning Huang, Chau-Jong Wang, Chih-Li Lin, Hsin-Hua Li, An-Ting Yen, Chiung-Huei Peng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC complementary medicine and therapies, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Antioxidants (Basel, Switzerland) · 2025
    Article
  2. Review
  3. Frontiers in microbiology · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Chien-Ning HuangDepartment of Internal Medicine, Chung-Shan Medical University Hospital, Taichung, Taiwan.
Chau-Jong WangInstitute of Biochemistry, Microbiology and Immunology, Chung-Shan Medical University, Taichung, Taiwan.
Chih-Li LinInstitute of Medicine, Chung-Shan Medical University, Taichung, Taiwan.
Hsin-Hua LiInstitute of Medicine, Chung-Shan Medical University, Taichung, Taiwan.
An-Ting YenInstitute of Biochemistry, Microbiology and Immunology, Chung-Shan Medical University, Taichung, Taiwan.
Chiung-Huei PengDivision of Basic Medical Science, Hungkuang University, Taichung City, Taiwan. a222907@sunrise.hk.edu.tw.ORCID https://orcid.org/0000-0003-1833-5522
Chung Shan Medical University · TWChung Shan Medical University Hospital · TWHungkuang University · TW

Funding

Ministry of Science and Technology 108-2320-B241-003Ministry of Science and Technology 109-2320-B-040-021
6 · The paper itself

Abstract

backgroundInsulin resistance could be associated with the development of Alzheimer disease (AD). The neuropathological hallmarks of AD are beta amyloid (Aβ) produced from sequential cleavage initiated by β-secretase and degraded by insulin degradation enzyme (IDE), as well as hyperphosphorylation of tau (p-tau). Insulin action involves the cascades of insulin receptor substrates (IRS) and phosphatidylinositol 3-kinase (PI3K), while phosphorylation of IRS-1 at ser307 (p-

methodsThe subfractions F1 and F2 were prepared according to a succession of procedures. F1 was composed by quercetin glycosides and triterpene ester, and F2 contained a large amount of polysaccharides. The in vitro insulin resistance model was established by SK-N-MC cell line treated with palmitate. MTT was used to define the dose range, and thereby Western blot, ELISA, and the activity assay were used to detect the putative markers. One-way ANOVA was performed for the statistical analysis.

resultsTreatment of palmitate induced the level of p-

conclusionsIn conclusion, we demonstrated that AE would be a potential adjuvant to prevent insulin resistance and the associated pathogenesis of AD, and F2 seems more feasible to be developed.

Indexed as

Insulin ResistanceAbelmoschusAlzheimer DiseaseAmyloid beta-PeptidesCell LineCell SurvivalDipeptidyl Peptidase 4FruitHumansPlant ExtractsTaiwantau ProteinsAmyloid beta-PeptidesDipeptidyl Peptidase 4Plant Extractstau ProteinsAbelmoschus esculentusBeta amyloidDipeptidyl peptidase-4Insulin resistance

Identifiers

PMID33267804
PMCPMC7709418
OpenAlexW3109822237

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.