ArticleBMC plant biology2020
MfbHLH38, a Myrothamnus flabellifolia bHLH transcription factor, confers tolerance to drought and salinity stresses in Arabidopsis.
Article in BMC plant biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48 citing papers in PubMed, 88 citations in OpenAlex.
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- A cyclic nucleotide-gated channel gene HcCNGC11 positively regulates salt stress responses in kenaf (Hibiscus cannabinus L.).Plant molecular biology · 2026Article
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- Whole genome identification and operational analysis of theFrontiers in plant science · 2026Article
- Genome-wide identification and abiotic stress response analysis of the oatFrontiers in plant science · 2026Article
- The promise of resurrection plants in enhancing crop tolerance to water scarcity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Integrative ATAC-Seq and RNA-Seq Analysis Reveals Key Transcription Factors Mediating Low Salinity Adaptation in Penaeid Shrimp.International journal of molecular sciences · 2025Article
- Characterization of Critical Amino Acids in the Transport and Selectivity of the Plant NaInternational journal of molecular sciences · 2025Article
- Genome-wide characterization and expression analysis of the bHLH gene family in response to abiotic stresses in Zingiber officinale Roscoe.BMC genomics · 2025Article
- A bHLH Transcription Factor Confers Salinity Stress Tolerance inPlant direct · 2024Article
- Genome-Wide Identification of the bHLH Gene Family inInternational journal of molecular sciences · 2024Article
- Genome-wide identification of bHLH transcription factors in Kenaf (Physiology and molecular biology of plants : an international journal of functional plant biology · 2024Article
- Overexpression ofInternational journal of molecular sciences · 2024Article
- Exogenous betaine enhances salt tolerance of Glycyrrhiza uralensis through multiple pathways.BMC plant biology · 2024Article
- Systematic identification and expression analysis of bHLH gene family reveal their relevance to abiotic stress response and anthocyanin biosynthesis in sweetpotato.BMC plant biology · 2024Article
- Utilizing physiologies, transcriptomics, and metabolomics to unravel key genes and metabolites ofFrontiers in plant science · 2024Article
- Genome-wide identification and expression analysis of bHLH gene family revealed their potential roles in abiotic stress response, anthocyanin biosynthesis and trichome formation inFrontiers in plant science · 2024Article
- Overexpression of the potatoFrontiers in plant science · 2024Article
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Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThe basic helix-loop-helix (bHLH) proteins, a large transcription factors family, are involved in plant growth and development, and defensive response to various environmental stresses. The resurrection plant Myrothamnus flabellifolia is known for its extremely strong drought tolerance, but few bHLHs taking part in abiotic stress response have been unveiled in M. flabellifolia.
resultsIn the present research, we cloned and characterized a dehydration-inducible gene, MfbHLH38, from M. flabellifolia. The MfbHLH38 protein is localized in the nucleus, where it may act as a transcription factor. Heterologous expression of MfbHLH38 in Arabidopsis improved the tolerance to drought and salinity stresses, as determined by the studies on physiological indexes, such as contents of chlorophyll, malondialdehyde (MDA), proline (Pro), soluble protein, and soluble sugar, water loss rate of detached leaves, reactive oxygen species (ROS) accumulation, as well as antioxidant enzyme activities. Besides, MfbHLH38 overexpression increased the sensitivity of stomatal closure to mannitol and abscisic acid (ABA), improved ABA level under drought stress, and elevated the expression of genes associated with ABA biosynthesis and ABA responding, sucha as NCED3, P5CS, and RD29A.
conclusionsOur results presented evidence that MfbHLH38 enhanced tolerance to drought and salinity stresses in Arabidopsis through increasing water retention ability, regulating osmotic balance, decreasing stress-induced oxidation damage, and possibly participated in ABA-dependent stress-responding pathway.
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