Evidence map›Paper›PMID 33267258›Full record

ArticleEntropy (Basel, Switzerland)2019

EEG Characterization of the Alzheimer's Disease Continuum by Means of Multiscale Entropies.

Aarón Maturana-Candelas, Carlos Gómez, Jesús Poza, Nadia Pinto, Roberto Hornero

Abstract read
In one paragraph

Article in Entropy (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Diagnostic utility of electrophysiological markers for early and differential diagnosis of Alzheimer's, Frontotemporal, and Lewy Body dementias: A systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
  3. The entropic brain today.Brain : a journal of neurology · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Is EEG Entropy a Useful Measure for Alzheimer's Disease?Actas espanolas de psiquiatria · 2024
    Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aarón Maturana-CandelasBiomedical Engineering Group, E.T.S.I. de Telecomunicación, Universidad de Valladolid, 47011 Valladolid, Spain.ORCID 0000-0001-7445-6498
Carlos GómezBiomedical Engineering Group, E.T.S.I. de Telecomunicación, Universidad de Valladolid, 47011 Valladolid, Spain.ORCID 0000-0002-9488-0605
Jesús PozaBiomedical Engineering Group, E.T.S.I. de Telecomunicación, Universidad de Valladolid, 47011 Valladolid, Spain.ORCID 0000-0001-8577-9559
Nadia PintoInstituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), 4200-135 Porto, Portugal.ORCID 0000-0002-1903-4206
Roberto HorneroBiomedical Engineering Group, E.T.S.I. de Telecomunicación, Universidad de Valladolid, 47011 Valladolid, Spain.ORCID 0000-0001-9915-2570

Funding

European Commission and European Regional Development Fund 0378_AD_EEGWA_2_PFundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia e Inovação and FEDER POCI-01-0145-FEDER-007274Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia e Inovação and FEDER UID/MAT/00144/2013Ministerio de Ciencia, Innovación y Universidades and FEDER DPI2017-84280-R
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder with high prevalence, known for its highly disabling symptoms. The aim of this study was to characterize the alterations in the irregularity and the complexity of the brain activity along the AD continuum. Both irregularity and complexity can be studied applying entropy-based measures throughout multiple temporal scales. In this regard, multiscale sample entropy (MSE) and refined multiscale spectral entropy (rMSSE) were calculated from electroencephalographic (EEG) data. Five minutes of resting-state EEG activity were recorded from 51 healthy controls, 51 mild cognitive impaired (MCI) subjects, 51 mild AD patients (AD

Indexed as

AD continuumAlzheimer’s disease (AD)Electroencephalography (EEG)mild cognitive impairment (MCI)multiscale sample entropy (MSE)refined multiscale spectral entropy (rMSSE)

Identifiers

PMID33267258
PMCPMC7515033

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.