ArticleEntropy (Basel, Switzerland)2019
Integrated Information as a Measure of Cognitive Processes in Coupled Genetic Repressilators.
Article in Entropy (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Cellular signaling pathways as plastic, proto-cognitive systems: Implications for biomedicine.Patterns (New York, N.Y.) · 2023Review
- An Account of Models of Molecular Circuits for Associative Learning with Reinforcement Effect and Forced Dissociation.Sensors (Basel, Switzerland) · 2022Article
- An Integrated World Modeling Theory (IWMT) of Consciousness: Combining Integrated Information and Global Neuronal Workspace Theories With the Free Energy Principle and Active Inference Framework; Toward Solving the Hard Problem and Characterizing Agentic Causation.Frontiers in artificial intelligence · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Intercellular communication and its coordination allow cells to exhibit multistability as a form of adaptation. This conveys information processing from intracellular signaling networks enabling self-organization between other cells, typically involving mechanisms associated with cognitive systems. How information is integrated in a functional manner and its relationship with the different cell fates is still unclear. In parallel, drawn originally from studies on neuroscience, integrated information proposes an approach to quantify the balance between integration and differentiation in the causal dynamics among the elements in any interacting system. In this work, such an approach is considered to study the dynamical complexity in a genetic network of repressilators coupled by quorum sensing. Several attractors under different conditions are identified and related to proposed measures of integrated information to have an insight into the collective interaction and functional differentiation in cells. This research particularly accounts for the open question about the coding and information transmission in genetic systems.
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What OpenQuestion holds
Registered trials
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